Document Detail

Tacrolimus as basic immunosuppression in pregnancy after renal transplantation. A single-center experience.
MedLine Citation:
PMID:  16386528     Owner:  NLM     Status:  MEDLINE    
Renal transplantation restores fertility within an average of 6 months, so women of childbearing age are able to consider pregnancy. Successful pregnancies have been reported in recent years under different immunosuppressive regimens, but the optimal treatment to achieve the maximum safety for both the mother and fetus remains unclear. Tacrolimus has been demonstrated to provide long-term immunosuppression and prevent rejection in most renal transplants. It seems safe, but experience is limited compared with cyclosporine. We report our experience highlighting the high rate of successful pregnancies attained in women treated with tacrolimus as the basic immunosuppressant and advised of recommendations to achieve a healthy newborn. Renal function was preserved during the pregnancy. The puerperal period and the rate of gestation-related difficulties appeared similar to that of the general population.
J A Garcia-Donaire; M Acevedo; M J Gutiérrez; M J Manzanera; E Oliva; E Gutiérrez; A Andrés; J M Morales
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  37     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2006-01-02     Completed Date:  2006-02-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3754-5     Citation Subset:  IM    
Renal Transplant Unit, Hospital 12 de Octubre, Madrid, Spain.
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MeSH Terms
Immunosuppressive Agents / therapeutic use*
Kidney Transplantation / immunology*
Pregnancy Complications / immunology*
Pregnancy Outcome
Retrospective Studies
Tacrolimus / therapeutic use*
Reg. No./Substance:
0/Immunosuppressive Agents; 109581-93-3/Tacrolimus

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