| Tachyphylaxis to ethacrynic acid in the isolated atrium of guinea-pig and its relation to noradrenaline stores. | |
| | |
MedLine Citation:
|
PMID: 647159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1 The isolated electrically-paced atrium of the guinea-pig developed a dose-dependent increase in the force of contraction in response to ethacrynic acid (12-100 microgram/ml) which was blocked by pretreatment of the animals with reserpine but was unaffected by desipramine or colchicine added to the bathing medium. 2 There was a rapidly developing tachyphylaxis to repeated doses of ethacrynic acid which was not reversed by rest or incubation of the tissue with noradrenaline. 3 There was no cross tachyphylaxis between ethacrynic acid and tyramine, amphetamine or nicotine. 4 Ethacrynic acid (200 microgram/ml) decreased the noradrenaline content of the atria by 32%. 5 It is concluded that ethacrynic acid exerts its effects indirectly through the release of endogenous noradrenaline and that the mechanism of release seems to be different from that of other known indirect sympathomimetic drugs. |
| | |
Authors:
|
M A Khoyi; A Pousti; G Powis; M R Zarrindast |
Related Documents
:
|
7562119 - In situ intestinal absorption of 2-o-alpha-d-glucopyranosyl-l-ascorbic acid in guinea p... 8277249 - Biological activities of lipoteichoic acid and peptidoglycan-teichoic acid of bacillus ... 6278679 - Biochemical studies in infective amosite pneumoconiosis. 3610349 - Immunogenicity in guinea pigs and tolerance in grass pollen-sensitive volunteers of ent... 7390399 - Hydrazonopropionic acid, a new class of hypoglycemic substances. 2. influence of 2-(phe... 12864909 - The rat as a model animal for the growing pig in determining ileal amino acid digestibi... 8119289 - Characterization of the lipopolysaccharide of moraxella catarrhalis. structural analysi... 22107889 - White gels: an easy way to preserve methylene blue stained gels. 17146249 - Effect of thyroid hormones on distension-induced gastric acid and pepsin secretion in r... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: British journal of pharmacology Volume: 63 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1978 May |
Date Detail:
|
Created Date: 1978-07-15 Completed Date: 1978-07-15 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 191-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Dose-Response Relationship, Drug Ethacrynic Acid / pharmacology* Female Guinea Pigs Heart / drug effects* Heart Atria / drug effects Heart Rate / drug effects Male Myocardial Contraction / drug effects Nicotine / pharmacology Norepinephrine / metabolism Tachyphylaxis* |
| Chemical | |
Reg. No./Substance:
|
51-41-2/Norepinephrine; 54-11-5/Nicotine; 58-54-8/Ethacrynic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The uptake and release of [3-H]-2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthlane (ADTN) by striata...
Next Document: Interaction of pentobarbitone and gamma-aminobutyric acid on mammalian sympathetic ganglion cells.