Document Detail

Tachyphylaxis and sensitization to nicotine-induced tachycardiac and pressor effects after nicotine infusions.
MedLine Citation:
PMID:  9204607     Owner:  NLM     Status:  MEDLINE    
This work examined the effects of nicotine on mean arterial pressure and heart rate in non-anesthetized spinal rats. Nicotine (200 mg/kg) was administered as a single bolus, as infusions lasting 7.5, 15 or 30 min, and as a post-infusion bolus. A nicotine bolus increased pressure and rate. These effects were less marked as the rate of infusion decreased. The infusions affected differentially the effects of a subsequent bolus. Thus, while tachycardia was decreased, the blood pressure rise was increased. An initial transient bradycardia was observed after bolus administration, but not during infusions; this effect was unchanged after post-infusion boluses. Pharmacological analysis indicated that tachycardia and bradycardia were predominantly due to ganglionic stimulation, while adrenal and sympathetic nerve catecholamine release played a major role in the pressor response. These results indicate that slow nicotine infusions do not induce tachyphylaxis for all of the cardiovascular effects of a subsequent bolus, and that development of acute tolerance appears to depend on the mechanism of action of the response.
S L Cruz; H Vidrio
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of medical research     Volume:  28     ISSN:  0188-4409     ISO Abbreviation:  Arch. Med. Res.     Publication Date:  1997  
Date Detail:
Created Date:  1997-08-14     Completed Date:  1997-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9312706     Medline TA:  Arch Med Res     Country:  MEXICO    
Other Details:
Languages:  eng     Pagination:  189-94     Citation Subset:  IM    
Sección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV, IPN, México, D.F.
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MeSH Terms
Blood Pressure / drug effects*
Bradycardia / chemically induced,  physiopathology
Decerebrate State
Drug Administration Schedule
Ganglionic Blockers / pharmacology
Ganglionic Stimulants / administration & dosage,  pharmacology*,  toxicity
Guanethidine / pharmacology
Heart Rate / drug effects*
Hexamethonium / pharmacology
Hypertension / chemically induced,  physiopathology
Infusions, Intravenous
Injections, Intravenous
Nicotine / administration & dosage,  pharmacology*,  toxicity
Nicotinic Agonists / administration & dosage,  pharmacology*,  toxicity
Nicotinic Antagonists / pharmacology
Rats, Wistar
Sympatholytics / pharmacology
Tachycardia / chemically induced,  physiopathology
Reg. No./Substance:
0/Ganglionic Blockers; 0/Ganglionic Stimulants; 0/Nicotinic Agonists; 0/Nicotinic Antagonists; 0/Sympatholytics; 54-11-5/Nicotine; 55-65-2/Guanethidine; 60-26-4/Hexamethonium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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