Document Detail


Tachykininergic mediation of viscerosensitive responses to acute inflammation in rats: role of CGRP.
MedLine Citation:
PMID:  9038887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tachykinins, colocalized with calcitonin gene-related peptides (CGRP) in sensory afferents, are involved in viscerosensitive responses. We investigated the role of tachykinins and CGRP in both nociceptive and visceromotor responses to inflammation. Visceral pain was assessed by abdominal muscle contractions. Gastric emptying was evaluated after gavage with reconstituted milk containing 51Cr-labeled sodium chromate. Acetic acid or 9% NaCl was injected intraperitoneally before the meal. RP-67580, SR-48968, human CGRP [hCGRP-(8-37)], or their vehicles were injected before acetic acid or saline. RP-67580, SR-48968, or their vehicles were injected before CGRP and the meal. GR-73632 or GR-76349 was injected before the meal. Acetic acids inhibited gastric emptying and increased the number of abdominal contractions. RP-67580 reduced the inhibition of gastric emptying without affecting the abdominal response. SR-48968 only reduced the acetic acid-induced increase of abdominal contractions. hCGRP-(8-37) reduced both responses induced by acetic acid. CGRP mimicked the effects of acetic acid. RP-67580 abolished CGRP-induced gastric emptying inhibition, whereas SR-48968 only diminished visceral pain. GR-73632 reduced gastric emptying, and GR-64349 increased abdominal response. In inflammation, neurokinin receptors (NK1 and NK2) mediate the gastric emptying inhibition and visceral pain, respectively. These responses involve a release of CGRP.
Authors:
V Julia; L Buéno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  272     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-03-28     Completed Date:  1997-03-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G141-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Institut National de la Recherche Agronomique, Toulouse, France.
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MeSH Terms
Descriptor/Qualifier:
Abdominal Muscles / drug effects
Acetic Acid / pharmacology
Acute Disease
Animals
Calcitonin Gene-Related Peptide / pharmacology,  physiology*
Gastric Emptying / drug effects
Humans
Inflammation
Male
Muscle Contraction / drug effects
Pain / physiopathology
Rats
Rats, Wistar
Sodium Chloride / pharmacology
Tachykinins / agonists,  physiology*
Viscera / physiopathology*
Chemical
Reg. No./Substance:
0/Tachykinins; 64-19-7/Acetic Acid; 7647-14-5/Sodium Chloride; 83652-28-2/Calcitonin Gene-Related Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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