Document Detail

Tachykinin neuropeptides in cerebellar granule neurons: an immunocytochemical study.
MedLine Citation:
PMID:  15823799     Owner:  NLM     Status:  MEDLINE    
We previously demonstrated that exogenously administered neurokinin A and neurokinin B, but not substance P, increased the sensitivity of cultured cerebellar granule neurons (CGNs) to glutamate. In the present study, the presence of tachykinin neuropeptides in CGNs was tested by confocal-based immunofluorescence. We found that neurokinin A and neurokinin B are present in CGNs but absent in astrocytes while substance P is abundant in astrocytes but absent in CGNs. It is postulated that the different localization of tachykinin neuropeptides in CGNs and astroglial cells has a physiological role in the modulation of excitatory transmission.
C Barbato; M T Ciotti; A Serafino; C Severini; P Calissano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of histochemistry : EJH     Volume:  49     ISSN:  1121-760X     ISO Abbreviation:  Eur J Histochem     Publication Date:    2005 Jan-Mar
Date Detail:
Created Date:  2005-04-12     Completed Date:  2005-06-16     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  9207930     Medline TA:  Eur J Histochem     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  IM    
Istituto di Neurobiologia e Medicina Molecolare, CNR, Rome, Italy.
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MeSH Terms
Antibody Specificity
Astrocytes / chemistry,  cytology,  metabolism
Cells, Cultured
Cerebellum / chemistry*,  cytology,  metabolism
Cytoplasmic Granules
Fluorescent Antibody Technique
Microscopy, Confocal
Neurokinin A / analysis,  biosynthesis
Neurokinin B / analysis,  biosynthesis
Neurons / chemistry*,  cytology,  metabolism
Neuropeptides / analysis*,  biosynthesis
Substance P / analysis,  biosynthesis
Tachykinins / analysis*,  biosynthesis
Reg. No./Substance:
0/Neuropeptides; 0/Tachykinins; 33507-63-0/Substance P; 86933-74-6/Neurokinin A; 86933-75-7/Neurokinin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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