Document Detail


Tachykinin NK2 receptor antagonists decrease eicosanoid release in lung anaphylaxis.
MedLine Citation:
PMID:  8905345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two tachykinin NK2 receptor antagonists, MEN 10.627 c(Met-Asp-Trp-Phe-Dap-Leu) and MEN 10.376 [(Tyr5,Trp6,8,9,Lys10]neurokinin A-(4-10), were used to investigate the role of tachykinins in in vitro guinea-pig lung anaphylaxis. Both antagonists dose-dependently decreased bronchoconstriction and the release of thromboxane and prostaglandin E2 induced by antigen challenge in perfused sensitized lungs, but neither had any effect on the basal release of either eicosanoid. The findings indicated that tachykinins released by sensory nerve fibers may contribute to anaphylactic reactions by increasing arachidonic acid metabolite release.
Authors:
P Montuschi; D Currò; G Ciabattoni
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  313     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-02-27     Completed Date:  1997-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  R1-3     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Roma, Italy.
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MeSH Terms
Descriptor/Qualifier:
Anaphylaxis / metabolism
Animals
Bronchoconstriction
Dinoprostone / biosynthesis,  metabolism*,  physiology
Dose-Response Relationship, Drug
Guinea Pigs
Lung / drug effects,  metabolism*
Muscle, Smooth / physiology
Neurokinin A / analogs & derivatives*,  pharmacology
Peptide Fragments / pharmacology*
Peptides, Cyclic / pharmacology*
Receptors, Tachykinin / physiology
Thromboxane B2 / biosynthesis,  metabolism*,  physiology
Chemical
Reg. No./Substance:
0/Peptide Fragments; 0/Peptides, Cyclic; 0/Receptors, Tachykinin; 135306-85-3/neurokinin A(4-10), Tyr(5)-Trp(6,8,9)-Lys(10)-; 157351-81-0/MEN 10627; 363-24-6/Dinoprostone; 54397-85-2/Thromboxane B2; 86933-74-6/Neurokinin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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