Document Detail

Tachycardia in spontaneously hypertensive and normotensive rats after fusaric acid and bupicamide.
MedLine Citation:
PMID:  975616     Owner:  NLM     Status:  MEDLINE    
1. The effects of the dopamine-beta-hydroxylase inhibitors bupicamide, fusaric acid, FLA-63 and U-14,624 on blood pressure and heart rate of spontaneously hypertensive rats were examined. 2. Bupicamide and fusaric acid caused marked tachycardia whereas FLA-63 and U-14,624 caused modest bradycardia; all drugs decreased blood pressure. 3. In normotensive rats, fusaric acid caused the same degree of tachycardia as in spontaneously hypertensive rats, but blood pressure was only slightly reduced. 4. Tachycardia after fusaric acid was not due to increased sympathetic activity or decreased parasympathetic activity but required intact catecholamine stores. 5. It is concluded that fusaric acid causes tachycardia by releasing catecholamines indirectly and that a metabolite of fusaric acid is also involved.
M J Antonaccio; D Coté; T Cavaliere
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  3     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    1976 May-Jun
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  199-206     Citation Subset:  IM    
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MeSH Terms
Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide / pharmacology
Blood Pressure / drug effects
Drug Interactions
Fusaric Acid / analogs & derivatives,  pharmacology*
Heart Atria / drug effects
Heart Rate / drug effects*
Hypertension / physiopathology*
Phenylthiazolylthiourea / pharmacology
Picolinic Acids / pharmacology*
Proadifen / pharmacology
Propranolol / pharmacology
Reserpine / pharmacology
Time Factors
Reg. No./Substance:
0/Picolinic Acids; 14901-16-7/Phenylthiazolylthiourea; 26087-98-9/Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; 302-33-0/Proadifen; 50-55-5/Reserpine; 525-66-6/Propranolol; 536-69-6/Fusaric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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