| Tachycardia and coronary blood flow: non-invasive estimation during Valsalva manoeuvre and exercise. | |
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MedLine Citation:
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PMID: 8222537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Simultaneous changes in cycle length and coronary blood flow were studied during Valsalva manoeuvre and supine cycloergometer exercise test in 10 male patients (mean age 48 +/- 12 years) who had successfully undergone myocardial revascularization by surgical anastomosis of the left internal mammary artery on the left anterior descending coronary artery. Blood velocity curves in the left internal mammary artery were obtained by a non-invasive continuous-wave Doppler probe at rest, in the last phase of the expiratory effort of the Valsalva manoeuvre and at the maximum load attained during the exercise test. Mean arterial pressure by sphygmomanometer, and cardiac cycle length on the basis of Doppler recording were measured. Mean blood velocity, the length of the blood column entering the coronary bed at each cycle (cardiac cycle times mean velocity), an index of blood cell acceleration (the ratio of mean velocity to cardiac cycle), and an index of coronary resistance (the ratio of mean pressure to mean velocity), were calculated. For approximately the same change in cycle length, coronary resistance decreased in exercise, with an increased mean velocity, but increased in Valsalva, with no changes in mean velocity. The length of the blood column entering the coronary bed at each cycle was unchanged in exercise, with a marked increase in the acceleration index, while it decreased in Valsalva. Therefore, we hypothesize that tachycardia has a limiting effect on sympathetic coronary constriction in Valsalva when cardiac external work is decreased, and an additional vasodilatory effect on coronary bed in exercise when external work is increased. |
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Authors:
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M Ciccone; A Federici; D di Noia; A Cipressa; M Epifani; G Losano; P Rizzon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical physiology (Oxford, England) Volume: 13 ISSN: 0144-5979 ISO Abbreviation: Clin Physiol Publication Date: 1993 Sep |
Date Detail:
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Created Date: 1993-12-15 Completed Date: 1993-12-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8309768 Medline TA: Clin Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 525-33 Citation Subset: IM |
Affiliation:
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Istituto di Malattie dell' Apparato Cardiovascolare, Università degli studi di Bari, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / physiology Coronary Vessels / physiology* Exercise / physiology* Heart / physiology* Hemodynamics / physiology Humans Male Middle Aged Regional Blood Flow / physiology Tachycardia / physiopathology* Ultrasonics Valsalva Maneuver / physiology* Vascular Resistance / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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