Document Detail

TWEAKing renal injury.
MedLine Citation:
PMID:  17981571     Owner:  NLM     Status:  MEDLINE    
TWEAK is a recently identified cytokine of the TNF superfamiliy. Through activation of the Fn14 receptor, TWEAK regulates cell proliferation, cell death and inflammation. Recent studies show increased TWEAK and Fn14 expression in tubular cells during acute kidney injury as well as elevated urinary TWEAK levels in patients with active lupus nephritis. Furthermore, glomerular mesangial cells and renal tubular epithelial cells express the Fn14 receptor under the regulation of proinflammatory cytokines. TWEAK weakly increases cell death and promotes secretion of inflammatory mediators in non-stimulated mesangial cells. In addition, in a proinflammatory milieu, TWEAK induces apoptosis of mesangial and tubular cells. The available data suggest that TWEAK is a new player in kidney injury both at the glomerular and tubulointerstitial levels and might be a target for therapeutic intervention.
Ana Belen Sanz; Juan Antonio Moreno; Maria Dolores Sanchez-Nino; Alvaro C Ucero; Alberto Benito; Beatriz Santamaria; Pilar Justo; M Concepcion Izquierdo; Jesus Egido; Luis Miguel Blanco-Colio; Alberto Ortiz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-01-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  13     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  2008  
Date Detail:
Created Date:  2007-11-05     Completed Date:  2007-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  580-9     Citation Subset:  IM    
Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, 2040 Madrid, Spain.
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MeSH Terms
Acute Disease
Cell Death
Cell Proliferation
Kidney / injuries*,  metabolism,  pathology*
Kidney Glomerulus / metabolism
Models, Biological
Protein Structure, Tertiary
Receptors, Tumor Necrosis Factor / metabolism
Signal Transduction
Tumor Necrosis Factors / metabolism,  physiology*
Reg. No./Substance:
0/Receptors, Tumor Necrosis Factor; 0/TNFSF12 protein, human; 0/TWEAK receptor; 0/Tumor Necrosis Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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