Document Detail


TSLP polymorphisms are associated with asthma in a sex-specific fashion.
MedLine Citation:
PMID:  20560908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma in a sex-specific fashion.
METHODS: We conducted regular and sex-stratified analyses of association between SNPs in TSLP and asthma in families of children with asthma in Costa Rica. Significant findings were replicated in whites and African-American participants in the Childhood Asthma Management Program, in African-Americans in the Genomic Research on Asthma in the African Diaspora study, in whites and Hispanics in the Children's Health Study, and in whites in the Framingham Heart Study (FHS).
MAIN RESULTS: Two SNPs in TSLP (rs1837253 and rs2289276) were significantly associated with a reduced risk of asthma in combined analyses of all cohorts (P values of 2 × 10(-5) and 1 × 10(-5) , respectively). In a sex-stratified analysis, the T allele of rs1837253 was significantly associated with a reduced risk of asthma in males only (P = 3 × 10(-6) ). Alternately, the T allele of rs2289276 was significantly associated with a reduced risk of asthma in females only (P = 2 × 10(-4) ). Findings for rs2289276 were consistent in all cohorts except the FHS.
CONCLUSIONS: TSLP variants are associated with asthma in a sex-specific fashion.
Authors:
G M Hunninghake; M E Soto-Quirós; L Avila; H P Kim; J Lasky-Su; N Rafaels; I Ruczinski; T H Beaty; R A Mathias; K C Barnes; J B Wilk; G T O'Connor; W James Gauderman; H Vora; J W Baurley; F Gilliland; C Liang; J S Sylvia; B J Klanderman; S S Sharma; B E Himes; C J Bossley; E Israel; B A Raby; A Bush; A M Choi; S T Weiss; J C Celedón
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergy     Volume:  65     ISSN:  1398-9995     ISO Abbreviation:  Allergy     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-02     Completed Date:  2011-02-28     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1566-75     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group / genetics
Asthma / genetics*
Child
Cohort Studies
Costa Rica
Cytokines / genetics*
European Continental Ancestry Group / genetics
Female
Genetic Predisposition to Disease / ethnology,  genetics*
Genome-Wide Association Study
Genotype
Hispanic Americans / genetics
Humans
Male
Polymorphism, Single Nucleotide
Risk Factors
Sex Characteristics*
Grant Support
ID/Acronym/Agency:
2T15LM007092-16/LM/NLM NIH HHS; HL04370/HL/NHLBI NIH HHS; HL66289/HL/NHLBI NIH HHS; K01 HL004370/HL/NHLBI NIH HHS; K01 HL004370-02/HL/NHLBI NIH HHS; K08 HL092222/HL/NHLBI NIH HHS; K08 HL092222-03/HL/NHLBI NIH HHS; K08 HL096833/HL/NHLBI NIH HHS; K08HL092222/HL/NHLBI NIH HHS; K12 HL089990/HL/NHLBI NIH HHS; N01 HC025195/HC/NHLBI NIH HHS; N01-HC25195/HC/NHLBI NIH HHS; P01 ES011627/ES/NIEHS NIH HHS; P01 ES011627/ES/NIEHS NIH HHS; P01 ES011627-010003/ES/NIEHS NIH HHS; P01 HL083069/HL/NHLBI NIH HHS; P01 HL083069/HL/NHLBI NIH HHS; P01 HL083069-02/HL/NHLBI NIH HHS; P30 ES007048/ES/NIEHS NIH HHS; P30 ES007048-04S19001/ES/NIEHS NIH HHS; R00 HL096840/HL/NHLBI NIH HHS; R01 HL066289/HL/NHLBI NIH HHS; R01 HL066289-01/HL/NHLBI NIH HHS; R01 HL086601/HL/NHLBI NIH HHS; R01 HL086601-01/HL/NHLBI NIH HHS; R01 HL087680/HL/NHLBI NIH HHS; R01 HL087680-01/HL/NHLBI NIH HHS; R01 HL087699/HL/NHLBI NIH HHS; R01 HL087699/HL/NHLBI NIH HHS; R01 HL087699-01/HL/NHLBI NIH HHS; T15 LM007092/LM/NLM NIH HHS; T32 HL007427-19/HL/NHLBI NIH HHS; T32 HL07427/HL/NHLBI NIH HHS; U01 HL065899/HL/NHLBI NIH HHS; U01 HL065899-01/HL/NHLBI NIH HHS; U01 HL075419/HL/NHLBI NIH HHS; U01 HL075419-01/HL/NHLBI NIH HHS; U01 HL65899/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/thymic stromal lymphopoietin
Comments/Corrections

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