Document Detail

TSH suppressive therapy: an overview of long-term clinical consequences.
MedLine Citation:
PMID:  20363722     Owner:  NLM     Status:  MEDLINE    
An overview of long-term clinical consequences of TSH suppressive therapy provides evidence that serum TSH levels should be maintained at levels <0.1 mU/l in high-risk (stage III and IV) patients, whereas lower-risk patients should be allowed to have their TSH levels rise into the normal range after residual disease has been ruled out by imaging and/or stimulated thyroglobulin measurement. The proper management of patients with known residual thyroid cancer, who are also elderly or who have underlying serious comorbidities (e.g., osteoporosis, cardiovascular disease, diabetes), is uncertain and requires a high degree of clinical experience and judgment.
David S Cooper
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormones (Athens, Greece)     Volume:  9     ISSN:  1109-3099     ISO Abbreviation:  Hormones (Athens)     Publication Date:    2010 Jan-Mar
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-04-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101142469     Medline TA:  Hormones (Athens)     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  57-9     Citation Subset:  IM    
Division of Endocrinology and Metabolism, the Johns Hopkins University School of Medicine, Baltimore, USA.
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MeSH Terms
Neoplasm Recurrence, Local / prevention & control
Neoplasm Staging
Neoplasm, Residual
Practice Guidelines as Topic
Risk Factors
Thyroglobulin / blood
Thyroid Neoplasms / complications,  drug therapy*
Thyroid Nodule / complications,  drug therapy*
Thyrotropin / blood*
Thyroxine / adverse effects*,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
7488-70-2/Thyroxine; 9002-71-5/Thyrotropin; 9010-34-8/Thyroglobulin

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