| TSH and prolactin secretions in Hashimoto's thyroiditis following withdrawal of thyroid hormone therapy. | |
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MedLine Citation:
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PMID: 6796396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in the pituitary-thyroid axis in patients with Hashimoto's thyroiditis following withdrawal of thyroid suppressive therapy were analyzed. The group of patients with thyroid adenoma served as control (group I). Patients with Hashimoto's thyroiditis were divided into 2 groups on the basis of serum TSH levels 8 weeks after discontinuing the exogenous thyroid hormone (group II, less than 10 microunits/ml; group III, more than 10 microunits/ml). During treatment with L-T4(200 micrograms/day) or L-T3(50 micrograms/day), there was no significant difference in serum T4-I and T3 levels among the three groups. Following L-T4 withdrawal, basal serum TSH levels were higher at 2 to 8 weeks in groups II and III than in group I. Serum TSH response to TRH was greater at 4 to 8 weeks in groups II and III than in group I. Following L-T3 withdrawal, basal serum TSH levels were higher at 1 and 2 weeks in group II than in group I, while those of group III were consistently higher during the study. Higher TSH responses to TRH were observed at 1 to 8 weeks in groups II and III. Neither basal nor TRH-induced prolactin (PRL) secretion differed significantly among the three groups. We have demonstrated that pituitary TSH secretion in patients with Hashimoto's thyroiditis is affected more by withdrawal of thyroid hormone therapy than in patients with thyroid adenoma. In addition, the present findings suggest a difference between the sensitivity of thyrotrophs and lactotrophs in Hashimoto's thyroiditis after prolonged thyroid therapy is discontinued. |
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Authors:
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N Ohsawa; I Kobayashi; K Suwa; N Kamio; S Maruta; K Ohshima; H Fukuda; S Kobayashi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrinologia japonica Volume: 28 ISSN: 0013-7219 ISO Abbreviation: Endocrinol. Jpn. Publication Date: 1981 Jun |
Date Detail:
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Created Date: 1982-02-12 Completed Date: 1982-02-12 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376546 Medline TA: Endocrinol Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 329-34 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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drug therapy,
physiopathology Female Humans Prolactin / secretion* Substance Withdrawal Syndrome / physiopathology Thyroid Neoplasms / drug therapy, physiopathology Thyroiditis, Autoimmune / drug therapy, physiopathology* Thyrotropin / secretion* Thyrotropin-Releasing Hormone / pharmacology Thyroxine / blood, therapeutic use Triiodothyronine / blood, therapeutic use |
| Chemical | |
Reg. No./Substance:
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24305-27-9/Thyrotropin-Releasing Hormone; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-62-4/Prolactin; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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