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A TSH-CREB1-microRNA Loop Is Required for Thyroid Cell Growth.
MedLine Citation:
PMID:  21816899     Owner:  NLM     Status:  Publisher    
MicroRNA (miRNA or miR) are an important class of regulators that participate in such biological functions as development, cell proliferation, differentiation, and apoptosis. The aim of this study was to elucidate the role of miRNA in cell proliferation using a unique cell system, namely thyroid cells that require thyrotropin for their growth. Here, we report the identification of a set of five specific miRNA (miR-1, miR-28-A, miR-290-5p, miR-296-3p, and miR-297a), whose down-regulation by thyrotropin is required for thyroid cell growth. In fact, overexpression of these miRNA negatively affects cell growth. We show that three of these miRNA target cAMP-responsive element binding protein (CREB)1, a thyrotropin-activated transcription factor, and that CREB1 binds the regulatory regions of the down-regulated miRNA. Hence, these data indicate that a synergistic loop involving thyrotropin, CREB1, and miRNA is required for thyroid cell proliferation.
Vincenza Leone; Daniela D'Angelo; Angelo Ferraro; Pierlorenzo Pallante; Ileana Rubio; Massimo Santoro; Carlo Maria Croce; Alfredo Fusco
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-4
Journal Detail:
Title:  Molecular endocrinology (Baltimore, Md.)     Volume:  -     ISSN:  1944-9917     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801431     Medline TA:  Mol Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli (V.L., D.D., A.Fe., P.P., M.S., A.Fu.), Università degli Studi di Napoli "Federico II," Naples 80131, Italy; Naples Oncogenomic Center (V.L., A.Fe., P.P., M.S., A.Fu.), CEINGE (Centro Ingegneria Genetica)-Biotecnologie Avanzate, Naples, and European School of Molecular Medicine, Naples 80145, Italy; Department of Biological Sciences (I.R.), Federal University of São Paulo, São Paulo 05403, Brazil; Department of Molecular Virology (C.M.C.), Immunology, and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210.
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