| The TRPv1 receptor is a mediator of the exercise pressor reflex in rats. | |
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MedLine Citation:
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PMID: 20142275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The skeletal muscle exercise pressor reflex (EPR) induces increases in heart rate (HR) and mean arterial pressure (MAP) during physical activity. This reflex is activated during contraction by stimulation of afferent fibres responsive to mechanical distortion and/or the metabolic by-products of skeletal muscle work. The molecular mechanisms responsible for activating these afferent neurons have yet to be identified. It has been reported that activation of the transient receptor potential vanilloid 1 (TRPv1) receptor within skeletal muscle (localized to unmyelinated afferent fibres) elicits increases in MAP and HR similar to those generated by the EPR. Thus, we hypothesized that stimulation of the TRPv1 receptor during muscle contraction contributes to the activation of the EPR. The EPR was activated by electrically induced static muscle contraction of the hindlimb in decerebrate Sprague-Dawley rats (n = 61) before and after the administration of the TRPv1 receptor antagonists, capsazepine (Capz; 100 microg/100 microl), iodoresinaferatoxin (IRTX; 1 microg/100 microl), or Ruthenium Red (RR; 100 microg/100 microl). Static muscle contraction alone induced increases in both HR (8 +/- 2 bpm) and MAP (21 +/- 3 mmHg). The HR and MAP responses to contraction were significantly lower (P < 0.05) after the administration of Capz (2 +/- 1 bpm; 7 +/- 1 mmHg, respectively), IRTX (3 +/- 2 bpm; 5 +/- 3 mmHg, respectively) and RR (0 +/- 1, bpm; 5 +/- 2 mmHg, respectively). These data suggest that the TRPv1 receptor contributes importantly to activation of the EPR during skeletal muscle contraction in the rat. |
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Authors:
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Scott A Smith; Anna K Leal; Maurice A Williams; Megan N Murphy; Jere H Mitchell; Mary G Garry |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-02-08 |
Journal Detail:
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Title: The Journal of physiology Volume: 588 ISSN: 1469-7793 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-02 Completed Date: 2010-06-28 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
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Languages: eng Pagination: 1179-89 Citation Subset: IM |
Affiliation:
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Department of Physical Therapy, University of Texas Southwestern Medical Center, Dallas, TX, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects, physiology Capsaicin / analogs & derivatives, pharmacology Diterpenes / pharmacology Heart Rate / drug effects, physiology Hindlimb / drug effects, physiopathology Male Muscle Contraction / drug effects, physiology* Muscle, Skeletal / drug effects, physiology Physical Conditioning, Animal / physiology* Rats Rats, Sprague-Dawley Reflex / drug effects, physiology* Ruthenium Red / pharmacology TRPV Cation Channels / antagonists & inhibitors, drug effects, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL-070242/HL/NHLBI NIH HHS; HL-088422/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Diterpenes; 0/TRPV Cation Channels; 0/Trpv1 protein, rat; 0/capsazepine; 11103-72-3/Ruthenium Red; 404-86-4/Capsaicin; 57444-62-9/resiniferatoxin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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