Document Detail


TRPV1 Activation Attenuates High-Salt Diet-Induced Cardiac Hypertrophy and Fibrosis through PPAR-δ Upregulation.
MedLine Citation:
PMID:  25152753     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
High-salt diet-induced cardiac hypertrophy and fibrosis are associated with increased reactive oxygen species production. Transient receptor potential vanilloid type 1 (TRPV1), a specific receptor for capsaicin, exerts a protective role in cardiac remodeling that resulted from myocardial infarction, and peroxisome proliferation-activated receptors δ (PPAR-δ) play an important role in metabolic myocardium remodeling. However, it remains unknown whether activation of TRPV1 could alleviate cardiac hypertrophy and fibrosis and the effect of cross-talk between TRPV1 and PPAR-δ on suppressing high-salt diet-generated oxidative stress. In this study, high-salt diet-induced cardiac hypertrophy and fibrosis are characterized by significant enhancement of HW/BW%, LVEDD, and LVESD, decreased FS and EF, and increased collagen deposition. These alterations were associated with downregulation of PPAR-δ, UCP2 expression, upregulation of iNOS production, and increased oxidative/nitrotyrosine stress. These adverse effects of long-term high-salt diet were attenuated by chronic treatment with capsaicin. However, this effect of capsaicin was absent in TRPV1(-/-) mice on a high-salt diet. Our finding suggests that chronic dietary capsaicin consumption attenuates long-term high-salt diet-induced cardiac hypertrophy and fibrosis. This benefit effect is likely to be caused by TRPV1 mediated upregulation of PPAR-δ expression.
Authors:
Feng Gao; Yi Liang; Xiang Wang; Zongshi Lu; Li Li; Shanjun Zhu; Daoyan Liu; Zhencheng Yan; Zhiming Zhu
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Publication Detail:
Type:  Journal Article     Date:  2014-07-24
Journal Detail:
Title:  PPAR research     Volume:  2014     ISSN:  1687-4757     ISO Abbreviation:  PPAR Res     Publication Date:  2014  
Date Detail:
Created Date:  2014-08-25     Completed Date:  2014-08-25     Revised Date:  2014-08-27    
Medline Journal Info:
Nlm Unique ID:  101269101     Medline TA:  PPAR Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  491963     Citation Subset:  -    
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