| TRPM2 and pancreatic β-cell responses to oxidative stress. | |
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MedLine Citation:
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PMID: 21099268 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Recent reports have linked the adenine nucleotide 2nd messenger gated Ca (2+) channel TRPM2 with hydrogen peroxide-induced pancreatic β-cell death in mouse and rat systems. As β-cells are exposed in vivo to reactive oxygen species produced via the respiratory chain and NADPH oxidases (reviewed in (3, 4) ), these reports suggest the existence of a TRPM2-dependent signaling pathway involved in β-cell responses to redox stress. |
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Authors:
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Andrew M Scharenberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Islets Volume: 1 ISSN: 1938-2022 ISO Abbreviation: Islets Publication Date: 2009 Sep-Oct |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101495366 Medline TA: Islets Country: United States |
Other Details:
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Languages: eng Pagination: 165-6 Citation Subset: IM |
Affiliation:
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University of Washington School of Medicine Seattle Children's Research Institute, Seattle, WA 98103, USA. andrewms@u.washington.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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