Document Detail


TRPM2 and pancreatic β-cell responses to oxidative stress.
MedLine Citation:
PMID:  21099268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent reports have linked the adenine nucleotide 2nd messenger gated Ca (2+) channel TRPM2 with hydrogen peroxide-induced pancreatic β-cell death in mouse and rat systems. As β-cells are exposed in vivo to reactive oxygen species produced via the respiratory chain and NADPH oxidases (reviewed in (3, 4) ), these reports suggest the existence of a TRPM2-dependent signaling pathway involved in β-cell responses to redox stress.
Authors:
Andrew M Scharenberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Islets     Volume:  1     ISSN:  1938-2022     ISO Abbreviation:  Islets     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-03-31     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  101495366     Medline TA:  Islets     Country:  United States    
Other Details:
Languages:  eng     Pagination:  165-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Insulin-Secreting Cells / metabolism*,  physiology
Mice
Oxidation-Reduction
Oxidative Stress / genetics*,  physiology
Rats
Signal Transduction / genetics,  physiology
Stress, Physiological / genetics,  physiology
TRPM Cation Channels / genetics,  metabolism,  physiology*
Chemical
Reg. No./Substance:
0/TRPM Cation Channels; 0/TRPM2 protein, mouse

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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