| A TRP among the astrocytes. | |
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MedLine Citation:
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PMID: 23045334 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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TRP channels were first identified as membrane proteins mediating phototransduction in fruit flies (Cosens & Manning, 1969; Montell & Rubin, 1989). Astrocytes were initially referred to as the silent elements of the nervous system (Kuffler et al., 1966; Ransom & Goldring, 1973). At the time these discoveries were made, few would have suspected TRP channels and astrocytes could contribute significantly to our understanding of brain signaling. Recent findings, however, put TRP channels and astrocytes in the spotlight, describe their ability to modulate the activity of specific sets of synapses, and raise some interesting questions. What makes astrocytes capable of exerting cell-specific effects on inter-neuronal signals? How do different synapses respond to changes in astrocytic function and in the local micro-structure of the neuropil? Can astrocytes be considered good candidate targets for therapeutic intervention to treat neurological diseases? Here I discuss the recent developments on TRP channels and astrocytes that have made us aware of the many structural and functional features of synapses that still need to be discovered and that could lead a new avant-garde in decoding the cellular and molecular basis of brain (dys)function. |
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Authors:
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Annalisa Scimemi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-8 |
Journal Detail:
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Title: The Journal of physiology Volume: - ISSN: 1469-7793 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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NIH/NINDS. |
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