Document Detail


A TRP among the astrocytes.
MedLine Citation:
PMID:  23045334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
TRP channels were first identified as membrane proteins mediating phototransduction in fruit flies. Astrocytes were initially referred to as the silent elements of the nervous system. At the time these discoveries were made, few would have suspected TRP channels and astrocytes could contribute significantly to our understanding of brain signalling. Recent findings, however, put TRP channels and astrocytes in the spotlight, describe their ability to modulate the activity of specific sets of synapses, and raise some interesting questions. What makes astrocytes capable of exerting cell-specific effects on interneuronal signals? How do different synapses respond to changes in astrocytic function and in the local micro-structure of the neuropil? Can astrocytes be considered good candidate targets for therapeutic intervention to treat neurological diseases? Here I discuss the recent developments on TRP channels and astrocytes that have made us aware of the many structural and functional features of synapses that still need to be discovered and that could lead a new avant-garde in decoding the cellular and molecular basis of brain (dys)function.
Authors:
Annalisa Scimemi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review     Date:  2012-10-08
Journal Detail:
Title:  The Journal of physiology     Volume:  591     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-06-13     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  9-15     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytes / physiology*
GABA Plasma Membrane Transport Proteins / physiology
Synapses / physiology
Transient Receptor Potential Channels / physiology*
Grant Support
ID/Acronym/Agency:
NS002986/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/GABA Plasma Membrane Transport Proteins; 0/Transient Receptor Potential Channels
Comments/Corrections

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