| TRAIL and osteoprotegerin (OPG) expression in bladder urothelial carcinoma: correlation with clinicopathological parameters and prognosis. | |
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MedLine Citation:
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PMID: 23277172 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIMS: : To investigate the expression of tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and osteoprotegerin (OPG) in bladder urothelial carcinomas (UCs) and assess possible interrelations with other regulators of TRAIL induced apoptosis (p65/NF-κB, p-ERK1/2, p-AKT) and FGFR3, as well as to elucidate their potential involvement in bladder tumourigenesis and determine their potential prognostic utility. METHODS: : Paraffin embedded transurethral resection tissue from 128 patients with UC was immunostained for TRAIL and OPG as well as for p65/NF-κB, p-ERK1/2, p-AKT and FGFR3. RESULTS: : TRAIL and OPG were coexpressed in 96.6% of cases and positively interrelated. OPG expression was significantly different among histological grades, being higher in low-grade UCs and was inversely correlated with the presence of lymphovascular invasion (LVI). TRAIL also displayed an inverse relationship with histological grade, T-category and LVI. Both OPG and TRAIL expression were positively correlated with FGFR3 expression, the former relationship being marginal. Moreover, increased TRAIL expression was marginally correlated with lower NF-κB/p65 nuclear expression. Increased OPG expression adversely affected survival both in univariate and multivariate analysis. CONCLUSIONS: : OPG and TRAIL are frequently expressed and coexpressed in UCs, supporting the involvement of OPG in the resistance to TRAIL-driven apoptosis. Inhibition of NF-κB activation may also play a similar role, although less important. OPG emerged as an independent prognostic marker of adverse significance. |
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Authors:
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Georgia Levidou; Irene Thymara; Angelica A Saetta; Polyanthi Papanastasiou; Petros Pavlopoulos; Stratigoula Sakellariou; Paraskevi Fragkou; Efstratios Patsouris; Penelope Korkolopoulou |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pathology Volume: 45 ISSN: 1465-3931 ISO Abbreviation: Pathology Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0175411 Medline TA: Pathology Country: England |
Other Details:
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Languages: eng Pagination: 138-44 Citation Subset: IM |
Affiliation:
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First Department of Pathology, Laiko General Hospital, Athens, University School of Medicine, Athens, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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