| Tumor necrosis factor receptor-associated factor 6 (TRAF6) and TGFβ-activated kinase 1 (TAK1) play essential roles in the C-type lectin receptor signaling in response to Candida albicans infection. | |
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MedLine Citation:
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PMID: 23148225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tumor necrosis factor receptor-associated factor 6 (TRAF6) and TGFβ-activated kinase 1 (TAK1) are considered as key intermediates in Toll-like receptor (TLR) signaling. However, the role of TRAF6 and TAK1 in C-type lectin receptors (CLRs) in response to fungal infection has not been studied. In this study, we have utilized macrophages derived from TRAF6 knock-out mice and myeloid-specific TAK1-deficient mice and determined the role of TRAF6 and TAK1 in CLR-induced signal transduction events. We demonstrate that TRAF6 and TAK1 are required for NF-κB and JNK activation, and expression of proinflammatory cytokines in response to Candida albicans infection. Our results highlight TRAF6 and TAK1 as key components in the signaling cascade downstream of C-type lectin receptors and as critical mediators of the anti-fungal immune response. Therefore, our studies provide a mechanistic understanding of the host immune response to C. albicans, which has a significant impact for the development of anti-fungal therapeutics and in understanding risk-factors and determining susceptibility to C. albicans infection. |
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Authors:
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Sara Gorjestani; Bryant G Darnay; Xin Lin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-11-12 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 287 ISSN: 1083-351X ISO Abbreviation: J. Biol. Chem. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-31 Completed Date: 2013-03-25 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: United States |
Other Details:
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Languages: eng Pagination: 44143-50 Citation Subset: IM |
Affiliation:
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Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Candida albicans / immunology, physiology* Candidiasis / enzymology, genetics, immunology* Cells, Cultured Female Humans Lectins, C-Type / genetics, immunology* MAP Kinase Kinase Kinases / genetics, immunology* Macrophages / immunology, microbiology Male Mice Mice, Inbred C57BL Mice, Knockout Signal Transduction* TNF Receptor-Associated Factor 6 / genetics, immunology* |
| Grant Support | |
ID/Acronym/Agency:
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R01AI050848/AI/NIAID NIH HHS; R01GM065899/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lectins, C-Type; 0/TNF Receptor-Associated Factor 6; EC 2.7.11.25/MAP Kinase Kinase Kinases; EC 2.7.11.25/MAP kinase kinase kinase 7 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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