| TP receptor as a therapeutic target in atherosclerosis and related cardiovascular diseases. | |
| | |
MedLine Citation:
|
PMID: 18221089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It had already showed that several thromboxane A(2) receptor (TP receptor) antagonists might be utilized in the treatment of cardiovascular diseases. In addition, recent reports suggested that TP receptor antagonism may be able to restrict vascular inflammation in atherosclerotic vessels. In particular, S18886 has been developed as a non-prostanoid TP receptor antagonist derived from sulotroban that is characterized by a tetrahydronaphthalene ring as a spacer between the 4-cholophenylsulfonamide group and carboxylic acid. Several reports using experimental animal models of atherosclerosis indicated that S18886 caused a regression of advanced atherosclerosis. More recently, several studies and patents showed that new thromboxane modulators combined with another pharmacological activities have been developed. Ohtake et al. discovered TRA-418 (a benzene-condensed heterocyclic derivative) having a TP receptor antagonistic activity and a prostaglandin I(2) receptor agonistic activity. Cesagrande found that 4-methyl-N- (4-trans-nitrooxycyclohexyl)-N-(3-pyridinylmethyl)-1,3- benzenedicarboxamide is endowed with anti-thromboxane and NO-donor actions. Oketani et al. discovered that E3040, a novel benzothiazole derivative, inhibited TXA(2) synthase and 5-LO activities. EK112, a combined angiotensin II and TP receptor antagonist, was developed. These new compounds may be able to restrict further infiltration of inflammatory cells in atherosclerotic vessels, thus stabilizing vulnerable plaques in the related cardiovascular diseases. |
| | |
Authors:
|
Toshiaki Ishizuka; Hideaki Higashino |
Related Documents
:
|
2173579 - Angiotensin ii stimulates phosphoinositide turnover and phosphorylase through aii-1 rec... 6262059 - Effects of two different angiotensin ii antagonists on aldosterone secretion by isolate... 15797649 - Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on hu... 16989589 - The (pro)renin receptor: therapeutic consequences. 10467219 - Safety and efficacy of eprosartan, a new angiotensin ii receptor blocker. 8498969 - Angiotensin ii receptors: cloning and regulation. 10633039 - Pharmacophore/receptor models for gaba(a)/bzr subtypes (alpha1beta3gamma2, alpha5beta3g... 10777589 - Selective regulation of endogenous g protein-coupled receptors by arrestins in hek293 c... 23416319 - Activation requirements for metabotropic glutamate receptors. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Recent patents on cardiovascular drug discovery Volume: 1 ISSN: 1574-8901 ISO Abbreviation: Recent Pat Cardiovasc Drug Discov Publication Date: 2006 Nov |
Date Detail:
|
Created Date: 2008-01-28 Completed Date: 2008-02-15 Revised Date: 2011-11-10 |
Medline Journal Info:
|
Nlm Unique ID: 101263805 Medline TA: Recent Pat Cardiovasc Drug Discov Country: United Arab Emirates |
Other Details:
|
Languages: eng Pagination: 241-7 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Kinki University School of Medicine, Osaka-Sayama, Osaka 589-8511, Japan. ishizuka@med.kindai.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Atherosclerosis / drug therapy* Cardiovascular Diseases / drug therapy* Humans Hydrazines / therapeutic use Lipoxygenase Inhibitors Naphthalenes / therapeutic use Oxidative Stress Propionic Acids / therapeutic use Receptors, Thromboxane A2, Prostaglandin H2 / antagonists & inhibitors*, physiology Signal Transduction |
| Chemical | |
Reg. No./Substance:
|
0/3-((6-amino-(4-chlorobenzenesulfonyl)-2-methyl-5,6,7,8-tetrahydronapht)-1-yl)propionic acid; 0/Hydrazines; 0/Lipoxygenase Inhibitors; 0/Naphthalenes; 0/Propionic Acids; 0/Receptors, Thromboxane A2, Prostaglandin H2; 98299-61-7/SQ 29548 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The renin inhibitor aliskiren as novel treatment for cardiovascular disease.
Next Document: Recent patents on Rho signaling pathway as therapeutic target for cardiovascular diseases.