| TOR under stress: targeting TORC1 by Rho1 GTPase. | |
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MedLine Citation:
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PMID: 22918240 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the yeast Saccharomyces cerevisiae, small GTPase Rho1 controls polarized actin distribution and cell wall expansion in response to many different environmental and intracellular stimuli. Its activity is essential for cell survival and adaptation under various stress conditions. A recent study identified the TOR complex 1 (TORC1), a central regulator in cell growth and metabolism, as a direct target of the small GTPase. This novel crosstalk extends the signaling network of Rho1 into many TORC1-dependent processes and sheds light on how yeast cells coordinate polarized spatial expansion with mass increase. |
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Authors:
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Gonghong Yan; Yumei Lai; Yu Jiang |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-08-23 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 11 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-09-18 Completed Date: 2013-02-06 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 3384-8 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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HEK293 Cells Humans Models, Biological Saccharomyces cerevisiae / enzymology*, physiology* Saccharomyces cerevisiae Proteins / metabolism* Signal Transduction Stress, Physiological* Transcription Factors / metabolism* rho GTP-Binding Proteins / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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CA129821/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Saccharomyces cerevisiae Proteins; 0/TORC1 protein complex, S cerevisiae; 0/Transcription Factors; EC 3.6.5.2/rho GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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