Document Detail

TOR under stress: targeting TORC1 by Rho1 GTPase.
MedLine Citation:
PMID:  22918240     Owner:  NLM     Status:  MEDLINE    
In the yeast Saccharomyces cerevisiae, small GTPase Rho1 controls polarized actin distribution and cell wall expansion in response to many different environmental and intracellular stimuli. Its activity is essential for cell survival and adaptation under various stress conditions. A recent study identified the TOR complex 1 (TORC1), a central regulator in cell growth and metabolism, as a direct target of the small GTPase. This novel crosstalk extends the signaling network of Rho1 into many TORC1-dependent processes and sheds light on how yeast cells coordinate polarized spatial expansion with mass increase.
Gonghong Yan; Yumei Lai; Yu Jiang
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-08-23
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  11     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-18     Completed Date:  2013-02-06     Revised Date:  2013-09-17    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3384-8     Citation Subset:  IM    
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
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MeSH Terms
HEK293 Cells
Models, Biological
Saccharomyces cerevisiae / enzymology*,  physiology*
Saccharomyces cerevisiae Proteins / metabolism*
Signal Transduction
Stress, Physiological*
Transcription Factors / metabolism*
rho GTP-Binding Proteins / metabolism*
Grant Support
Reg. No./Substance:
0/Saccharomyces cerevisiae Proteins; 0/TORC1 protein complex, S cerevisiae; 0/Transcription Factors; EC GTP-Binding Proteins

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