Document Detail

TNM staging, histopathological grading, and tumor-associated antigens in patients with a history of mucoepidermoid carcinoma of the salivary glands.
MedLine Citation:
PMID:  10470165     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to evaluate the TNM categories and histopathological grading as prognostic factors in mucoepidermoid carcinoma (MEC). In addition, the study was designed to provide baseline data on levels of tumor-associated antigens (TAA) in sera of MEC patients. MATERIALS AND METHODS: Fifty-nine patients with MEC of the salivary glands were evaluated. RESULTS: Reclassified TNM stage, at the time of initial diagnosis, varied considerably. In disease-free patients, none of the tested sera were TAA elevated above the cut-off levels. Our patients who died of tumor metastasis had all been classified as stage III or IV at the time of initial diagnosis. Distant metastases are rarely found even decades after surgical therapy. CONCLUSIONS: Long-term follow-up is recommended for patients with MEC of the salivary glands. TAA are not elevated in disease-free patients. The value of TAA in the monitoring of MEC patients remains to be evaluated in further studies.
K Plambeck; R E Friedrich; M Bahlo; S Bartel-Friedrich; R Klapdor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  19     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1999 Jul-Aug
Date Detail:
Created Date:  1999-09-28     Completed Date:  1999-09-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  2397-404     Citation Subset:  IM    
Oral and Maxillofacial Surgery Clinic, Eppendorf University Hospital, University of Hamburg, Germany.
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MeSH Terms
Aged, 80 and over
Antigens, Neoplasm / analysis*
Carcinoma, Mucoepidermoid / classification,  mortality,  pathology*,  surgery
Disease-Free Survival
Follow-Up Studies
Middle Aged
Neoplasm Staging
Retrospective Studies
Salivary Gland Neoplasms / classification,  mortality,  pathology*,  surgery
Survival Analysis
Time Factors
Tumor Markers, Biological / analysis*
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Tumor Markers, Biological

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