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TNFSF15 Modulates Neovascularization and Inflammation.
MedLine Citation:
PMID:  22833050     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Tumor necrosis factor superfamily-15 (TNFSF15; also known as VEGI or TL1A) is a unique cytokine that functions in the modulation of vascular homeostasis and inflammation. TNFSF15 is expressed abundantly in established vasculature but is down-regulated at sites of neovascularization such as in cancers and wounds. TNFSF15 inhibits endothelial cell proliferation and endothelial progenitor cell differentiation. Additionally, TNFSF15 stimulates T cell activation, Th1 cytokine production, and dendritic cell maturation. Some of the functions of TNFSF15 are mediated by death receptor-3. We review the experimental evidences on TNFSF15 activities in angiogenesis, vasculogenesis, inflammation, and immune system mobilization.
Authors:
Zhisong Zhang; Lu-Yuan Li
Publication Detail:
Type:  Journal Article     Date:  2012-07-26
Journal Detail:
Title:  Cancer microenvironment : official journal of the International Cancer Microenvironment Society     Volume:  5     ISSN:  1875-2284     ISO Abbreviation:  Cancer Microenviron     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-10-11     Completed Date:  2012-10-12     Revised Date:  2013-02-19    
Medline Journal Info:
Nlm Unique ID:  101322634     Medline TA:  Cancer Microenviron     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  237-47     Citation Subset:  -    
Affiliation:
College of Pharmacy, Nankai University, Tianjin, China.
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