Document Detail

TNFRp55 controls regulatory T cell responses in Yersinia-induced reactive arthritis.
MedLine Citation:
PMID:  23207279     Owner:  NLM     Status:  Publisher    
In addition to its well-known pro-inflammatory effects, tumor necrosis factor (TNF) displays anti-inflammatory activities through mechanisms poorly understood. Previously, we reported the development of severe chronic Yersinia enterocolitica-induced reactive arthritis (ReA) in mice lacking the TNF receptor (TNFR)p55. As regulatory T (T(reg)) cells limit chronic inflammation, here we aim to investigate the expansion and function of CD4(+)CD25(+)FoxP3(+) T(reg) cells in the ReA animal model. The number of T(reg) cells as well as the FoxP3 mRNA expression and interleukin (IL)-10 levels were significantly decreased in joint regional lymph nodes (RLNs) of TNFRp55(-/-) mice vs wild-type (WT) mice at the arthritis onset. However, at chronic phase of arthritis, the number of T(reg) cell in TNFRp55(-/-) was similar to WT mice. To explore the in vivo function of T(reg) cells at this chronic phase in WT and TNFRp55-deficient mice, we adoptively transferred CD4(+) T cells from TNFRp55-deficient mice of day 21, into naïve WT or TNFRp55(-/-) mice. When knockout mice were used as recipients we observed higher delayed-type hypersensitivity (DTH) responses and joint inflammation after heat-killed Yersinia (HKY) stimulation. Accordingly, we found higher levels of IL-17, interferon (IFN)-γ, IL-6, transforming growth factor (TGF)-β1 and IL-12/23p40 and lower IL-10 levels in RLN of paws challenged with HKY in TNFRp55(-/-) recipient mice. In addition, we found that CD4(+) T cells from TNFRp55(-/-) mice controlled antigen-specific IL-12/23(p40) production in recipient WT mice. Our results show that TNFRp55 controls the induction and function of T(reg) cells through differential regulation of cytokine production, suggesting a novel molecular target for immune intervention in ReA.Immunology and Cell Biology advance online publication, 4 December 2012; doi:10.1038/icb.2012.65.
Ethelina Cargnelutti; José L Arias; Susana R Valdez; Gabriel A Rabinovich; María S Di Genaro
Related Documents :
23097619 - One injection of dsred followed by bites from transgenic mosquitoes producing dsred in ...
20620199 - Genetic inactivation of pleiotrophin triggers amphetamine-induced cell loss in the subs...
25029349 - Rhinovirus infection induces il-13 production from cd11b-positive, exudative m2-polariz...
24698979 - Inhibition of soluble tumor necrosis factor is therapeutic in huntington's disease.
23468309 - Soy protein inhibits inflammation-induced vcam-1 and inflammatory cytokine induction by...
24577479 - Selenomethionine ameliorates cognitive decline, reduces tau hyperphosphorylation, and r...
15969689 - Recombinant mycobacterium bovis bcg producing il-18 reduces il-5 production and broncho...
10222259 - Vascular response to angiotensin ii is exaggerated through an upregulation of at1 recep...
18714819 - Effect of electromagnetic pulse exposure on permeability of blood-testicle barrier in m...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-04
Journal Detail:
Title:  Immunology and cell biology     Volume:  -     ISSN:  1440-1711     ISO Abbreviation:  Immunol. Cell Biol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706300     Medline TA:  Immunol Cell Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Immunology, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis; Laboratory of Immunopathology, Multidisciplinary Institute of Biological Investigations-San Luis (IMIBIO-SL), National Council of Scientific and Technical Investigations (CONICET), San Luis, Argentina.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so f...
Next Document:  T-cell intrinsic and extrinsic mechanisms of p27Kip1 in the regulation of CD8 T-cell memory.