Document Detail

TNF-related apoptosis-inducing ligand and its decoy receptor osteoprotegerin in nonischemic dilated cardiomyopathy.
MedLine Citation:
PMID:  16288714     Owner:  NLM     Status:  MEDLINE    
Apoptosis has been attributed an essential role in dilated cardiomyopathy (DCM) recently. We assessed expression of TNF-related apoptosis-inducing ligand (TRAIL) and its decoy receptor osteoprotegerin (OPG) in men with nonischemic DCM, who underwent coronary angiography and endomyocardial biopsy (EMB) after exclusion of coronary artery disease compared to control patients. TRAIL plasma concentrations were elevated in DCM (p=0.02 vs. controls), and were positively correlated with left ventricular enddiastolic diameter (r=0.15, p=0.04), whereas OPG plasma levels did not differ between both groups (p=0.96). In EMB of DCM patients, TRAIL and OPG protein were detected by immunohistochemistry but not in controls. Furthermore, gene expression in EMB or peripheral blood leukocytes (PBL) of DCM patients assessed by real-time PCR showed an increase of TRAIL mRNA in PBL (p=0.01 vs. controls), whereas OPG mRNA was upregulated in endomyocardial specimens (p<0.001 vs. controls). In conclusion, myocardial overexpression of antiapoptotic OPG in DCM patients may represent a compensatory mechanism to limit systemic activation of TRAIL in patients with congestive heart disease.
Michael Schoppet; Volker Ruppert; Lorenz C Hofbauer; Stephanie Henser; Nadia Al-Fakhri; Michael Christ; Sabine Pankuweit; Bernhard Maisch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-02
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  338     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-23     Completed Date:  2006-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1745-50     Citation Subset:  IM    
Department of Internal Medicine and Cardiology, Philipps-University, D-35033 Marburg, Germany.
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MeSH Terms
Apoptosis Regulatory Proteins / biosynthesis*
Cardiomyopathy, Dilated / physiopathology*
Fetal Heart / metabolism
Gene Expression Regulation
Glycoproteins / biosynthesis*
Membrane Glycoproteins / biosynthesis*
Middle Aged
Myocardium / metabolism
Receptors, Cytoplasmic and Nuclear / biosynthesis*
Receptors, Tumor Necrosis Factor / biosynthesis*
TNF-Related Apoptosis-Inducing Ligand
Tumor Necrosis Factor-alpha / biosynthesis*
Ventricular Dysfunction, Left / physiopathology
Reg. No./Substance:
0/Apoptosis Regulatory Proteins; 0/Glycoproteins; 0/Membrane Glycoproteins; 0/Osteoprotegerin; 0/Receptors, Cytoplasmic and Nuclear; 0/Receptors, Tumor Necrosis Factor; 0/TNF-Related Apoptosis-Inducing Ligand; 0/TNFRSF11B protein, human; 0/TNFSF10 protein, human; 0/Tumor Necrosis Factor-alpha

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