Document Detail

TNF-receptor levels in preeclampsia--results of a longitudinal study in high-risk women.
MedLine Citation:
PMID:  16390786     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) is thought to play a role in immune activation in preeclampsia. The objective of this study was to establish if soluble TNF-receptor I (sTNF-rI) levels relate to the onset and severity of preeclampsia. METHODS: Maternal plasma sTNF-rI levels were studied throughout pregnancy in 68 women with a history of severe preeclampsia or intra-uterine growth restriction (IUGR), and primigravidas with chronic hypertension. Data are presented as mean (SD) in ng/ml. RESULTS: In the second trimester there was a significant difference in sTNF-rI levels between preeclamptic pregnancies with and without IUGR (means 1.33 (0.20) and 1.11 (0.15) respectively, p < 0.005). In severe preeclampsia with delivery before 34 weeks of gestation, sTNF-rI levels were higher than in mild preeclampsia in the second and third trimesters (means 1.40 (0.16) vs. 1.16 (0.19), p < 0.02 and 1.82 (0.47) vs. 1.42 (0.22), p < 0.05, respectively). CONCLUSION: sTNF-rI levels were higher in preeclampsia with fetal involvement, suggesting that increased TNF-alpha production in preeclampsia is related to impaired placentation rather than to the maternal syndrome.
Elbert-Jaap I Schipper; Antoinette C Bolte; Casper G Schalkwijk; Herman P Van Geijn; Gustaaf A Dekker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  18     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2006-01-04     Completed Date:  2006-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  283-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Vrije Universiteit Medical Center, Amsterdam, the Netherlands.
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MeSH Terms
Fetal Growth Retardation / blood
Gestational Age
Longitudinal Studies
Pre-Eclampsia / blood*
Receptors, Tumor Necrosis Factor, Type I / blood*
Risk Factors
Severity of Illness Index
Reg. No./Substance:
0/Receptors, Tumor Necrosis Factor, Type I

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