| TNF-receptor levels in preeclampsia--results of a longitudinal study in high-risk women. | |
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MedLine Citation:
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PMID: 16390786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) is thought to play a role in immune activation in preeclampsia. The objective of this study was to establish if soluble TNF-receptor I (sTNF-rI) levels relate to the onset and severity of preeclampsia. METHODS: Maternal plasma sTNF-rI levels were studied throughout pregnancy in 68 women with a history of severe preeclampsia or intra-uterine growth restriction (IUGR), and primigravidas with chronic hypertension. Data are presented as mean (SD) in ng/ml. RESULTS: In the second trimester there was a significant difference in sTNF-rI levels between preeclamptic pregnancies with and without IUGR (means 1.33 (0.20) and 1.11 (0.15) respectively, p < 0.005). In severe preeclampsia with delivery before 34 weeks of gestation, sTNF-rI levels were higher than in mild preeclampsia in the second and third trimesters (means 1.40 (0.16) vs. 1.16 (0.19), p < 0.02 and 1.82 (0.47) vs. 1.42 (0.22), p < 0.05, respectively). CONCLUSION: sTNF-rI levels were higher in preeclampsia with fetal involvement, suggesting that increased TNF-alpha production in preeclampsia is related to impaired placentation rather than to the maternal syndrome. |
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Authors:
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Elbert-Jaap I Schipper; Antoinette C Bolte; Casper G Schalkwijk; Herman P Van Geijn; Gustaaf A Dekker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 18 ISSN: 1476-7058 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2006-01-04 Completed Date: 2006-05-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: United States |
Other Details:
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Languages: eng Pagination: 283-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Vrije Universiteit Medical Center, Amsterdam, the Netherlands. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Fetal Growth Retardation / blood Gestational Age Humans Longitudinal Studies Pre-Eclampsia / blood* Pregnancy Receptors, Tumor Necrosis Factor, Type I / blood* Risk Factors Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Tumor Necrosis Factor, Type I |
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