| TNF-alpha, TNF-beta and IL-4 gene polymorphisms in Iranian patients with multiple sclerosis. | |
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MedLine Citation:
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PMID: 17295710 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To investigate the association between tumor necrosis factor-alpha (TNF-alpha) G-308A, tumor necrosis factor-beta (TNF-beta) G+252A and interleukin-4 (IL-4) C-590T polymorphisms and susceptibility to multiple sclerosis (MS) development and clinical course of the disease. MATERIALS AND METHODS: Two hundred and seventy patients with MS and 542 sex and ethnic matched controls were enrolled in the present study. An allele-specific oligonucleotide polymerase chain reaction was used to detect the polymorphism at position -308 of the TNF-alpha gene. The genotypes of TNF-beta and IL-4 were determined by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: Allelic and genotypic frequencies for these polymorphisms were similar in patients with MS and population controls or among different types of the disease. CONCLUSION: The results of the present study suggest that the three mentioned functional polymorphisms are not likely to cause susceptibility to MS in the Iranian population. |
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Authors:
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E Kamali-Sarvestani; A Nikseresht; E Aflaki; J Sarvari; B Gharesi-Fard |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 115 ISSN: 0001-6314 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-13 Completed Date: 2007-04-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 161-6 Citation Subset: IM |
Affiliation:
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Department of Immunology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. immunol2@sums.ac.ir |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Disability Evaluation Female Genotype Humans Inheritance Patterns / genetics Interleukin-4 / genetics* Iran Lymphotoxin-alpha / genetics* Male Multiple Sclerosis / genetics* Polymorphism, Genetic / genetics* Tumor Necrosis Factor-alpha / genetics* |
| Chemical | |
Reg. No./Substance:
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0/IL4 protein, human; 0/Lymphotoxin-alpha; 0/Tumor Necrosis Factor-alpha; 207137-56-2/Interleukin-4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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