Document Detail


TNF-alpha, TNF-beta and IL-4 gene polymorphisms in Iranian patients with multiple sclerosis.
MedLine Citation:
PMID:  17295710     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To investigate the association between tumor necrosis factor-alpha (TNF-alpha) G-308A, tumor necrosis factor-beta (TNF-beta) G+252A and interleukin-4 (IL-4) C-590T polymorphisms and susceptibility to multiple sclerosis (MS) development and clinical course of the disease. MATERIALS AND METHODS: Two hundred and seventy patients with MS and 542 sex and ethnic matched controls were enrolled in the present study. An allele-specific oligonucleotide polymerase chain reaction was used to detect the polymorphism at position -308 of the TNF-alpha gene. The genotypes of TNF-beta and IL-4 were determined by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: Allelic and genotypic frequencies for these polymorphisms were similar in patients with MS and population controls or among different types of the disease. CONCLUSION: The results of the present study suggest that the three mentioned functional polymorphisms are not likely to cause susceptibility to MS in the Iranian population.
Authors:
E Kamali-Sarvestani; A Nikseresht; E Aflaki; J Sarvari; B Gharesi-Fard
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  115     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-13     Completed Date:  2007-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  161-6     Citation Subset:  IM    
Affiliation:
Department of Immunology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. immunol2@sums.ac.ir
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Disability Evaluation
Female
Genotype
Humans
Inheritance Patterns / genetics
Interleukin-4 / genetics*
Iran
Lymphotoxin-alpha / genetics*
Male
Multiple Sclerosis / genetics*
Polymorphism, Genetic / genetics*
Tumor Necrosis Factor-alpha / genetics*
Chemical
Reg. No./Substance:
0/IL4 protein, human; 0/Lymphotoxin-alpha; 0/Tumor Necrosis Factor-alpha; 207137-56-2/Interleukin-4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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