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TNF Receptor-1 Is Required for the Formation of Splenic Compartments during Adult, but Not Embryonic Life.
MedLine Citation:
PMID:  21187446     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Lymphotoxin β-receptor (LTβR) and TNF receptor-1 (TNFR1) are important for the development of secondary lymphoid organs during embryonic life. The significance of LTβR and TNFR1 for the formation of lymphoid tissue during adult life is not well understood. Immunohistochemistry, morphometry, flow cytometry, and laser microdissection were used to compare wild-type, LTβR(-/-), TNFR1(-/-) spleens with splenic tissue that has been newly formed 8 wk after avascular implantation into adult mice. During ontogeny, LTβR is sufficient to induce formation of the marginal zone, similar-sized T and B cell zones, and a mixed T/B cell zone that completely surrounded the T cell zone. Strikingly, in adult mice, the formation of splenic compartments required both LTβR and TNFR1 expression, demonstrating that the molecular requirements for lymphoid tissue formation are different during embryonic and adult life. Thus, interfering with the TNFR1 pathway offers the possibility to selectively block the formation of ectopic lymphoid tissue and at the same time to spare secondary lymphoid organs such as spleen and lymph nodes. This opens a new perspective for the treatment of autoimmune and inflammatory diseases.
Authors:
Novica M Milicevic; Karola Klaperski; Klaus Nohroudi; Zivana Milicevic; Katja Bieber; Babett Baraniec; Maike Blessenohl; Kathrin Kalies; Carl F Ware; Jürgen Westermann
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Publication Detail:
Type:  Journal Article     Date:  2010-12-27
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  186     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1486-94     Citation Subset:  AIM; IM    
Affiliation:
Institute of Histology and Embryology, Faculty of Medicine, University of Beograd, 11000 Beograd, Serbia;
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