| TNF-α and the Development of the Neonatal Immune System: Implications for Inhibitor Use in Pregnancy. | |
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MedLine Citation:
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PMID: 21468063 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Inflammatory bowel diseases, Crohn's disease, and ulcerative colitis have an unpredictable course during and after pregnancy (1). There is a great deal of interest in treating moderate to severe active inflammatory bowel disease with anti-tumor necrosis factor (anti-TNF) biologics in pregnant women (2). We lack definitive information about the effects of these agents on the development of the immune system of the human fetus and the newborn baby. Anti-TNF agents fall within US Food and Drug Administration's (FDA) category B regarding fetal risk, indicating that no adequate and well-controlled studies have been conducted in pregnant or nursing women. Here, we review animal studies (of both mice and nonhuman primates) that examine the role of TNF and its inhibitors in the normal development of the immune system. |
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Authors:
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Razvan Arsenescu; Violeta Arsenescu; Willem J S de Villiers |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 106 ISSN: 1572-0241 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 559-62 Citation Subset: IM |
Affiliation:
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Department of Digestive Diseases and Nutrition, University of Kentucky, Lexington, Kentucky, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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