Document Detail

TNF-alpha/IL-10 ratio and C-reactive protein as markers of the inflammatory response in CAD-prone North Indian patients with acute myocardial infarction.
MedLine Citation:
PMID:  19576194     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cytokines are responsible for the modulation of immunological and inflammatory processes and play a significant role in the pathogenesis of coronary artery disease (CAD). Tumor necrosis factor (TNF)-alpha is the major pro-inflammatory cytokine while interleukin-10 (IL-10) is the major anti-inflammatory cytokine in patients with CAD. We determined the significance of the TNF/IL-10 ratio and C-reactive protein (CRP) in patients of acute myocardial infarction as a marker for CAD in the atherosclerosis-prone North Indian population. METHODS: The study group comprised of 100 patients of acute myocardial infarction (AMI) and 100 age and sex matched healthy controls. Lipid profile, apolipoprotein-A (Apo-A), apolipoprotein-B (Apo-B) and CRP concentrations were estimated using commercially available kits in all patients and control subjects. TNF-alpha, lipoprotein (a) (Lp(a)) and IL-10 concentrations were assayed by using commercially available ELISA kits. RESULTS: The TNF-alpha concentrations were significantly higher in patients with acute myocardial infarction (86.9+/-4.7 pg/ml), as compared to control subjects (7.1+/-0.67 g/ml). AMI patients also exhibited higher serum concentrations of IL-10 (5.74+/-0.82 pg/ml), in comparison to the controls (1.22+/-0.06 pg/ml). The ratio of TNF-alpha to IL-10 was significantly increased in cases (15.2+/-1.13), in comparison to healthy subjects (5.8+/-0.64). CONCLUSIONS: These cytokines underline the role of the immune processes during unstable atherosclerosis and in the pathogenesis of coronary artery disease in the Indian context.
Binita Goswami; Medha Rajappa; V Mallika; Deepak Kumar Shukla; Suresh Kumar
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Publication Detail:
Type:  Journal Article     Date:  2009-07-01
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  408     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-14     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  14-8     Citation Subset:  IM    
Department of Biochemistry, G. B. Pant Hospital, New Delhi-110002, India.
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MeSH Terms
Biological Markers / metabolism
C-Reactive Protein / metabolism*
Case-Control Studies
Coronary Artery Disease / complications*,  metabolism*
Inflammation / metabolism
Interleukin-10 / metabolism*
Lipid Metabolism
Middle Aged
Myocardial Infarction / complications*,  diagnosis,  metabolism
Regression Analysis
Tumor Necrosis Factor-alpha / metabolism*
Reg. No./Substance:
0/Biological Markers; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 9007-41-4/C-Reactive Protein

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