Document Detail


TMS interference with primacy and recency mechanisms reveals bimodal episodic encoding in the human brain.
MedLine Citation:
PMID:  23198892     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A classic finding of the psychology of memory is the "serial position effect." Immediate free recall of a word list is more efficient for items presented early (primacy effect) or late (recency effect), with respect to those in the middle. In an event-related, randomized block design, we interfered with the encoding of unrelated words lists with brief trains of repetitive TMS (rTMS), applied coincidently with the acoustic presentation of each word to the left dorsolateral pFC, the left intraparietal lobe, and a control site (vertex). Interference of rTMS with encoding produced a clear-cut double dissociation on accuracy during immediate free recall. The primacy effect was selectively worsened by rTMS of the dorsolateral pFC, whereas recency was selectively worsened by rTMS of the intraparietal lobe. These results are in agreement with the double dissociation between short-term and long-term memory observed in neuropsychological patients and provide direct evidence of distinct cortical mechanisms of encoding in the human brain.
Authors:
Iglis Innocenti; Stefano F Cappa; Matteo Feurra; Fabio Giovannelli; Emiliano Santarnecchi; Giovanni Bianco; Massimo Cincotta; Simone Rossi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cognitive neuroscience     Volume:  25     ISSN:  1530-8898     ISO Abbreviation:  J Cogn Neurosci     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910747     Medline TA:  J Cogn Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-16     Citation Subset:  IM    
Affiliation:
Azienda Ospedaliera Universitaria Senese, Siena, Italy.
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