Document Detail

TLR9 signaling defines distinct prognostic subsets in CLL.
MedLine Citation:
PMID:  23276930     Owner:  NLM     Status:  MEDLINE    
Chronic lymphocytic leukemia (CLL) is a common B-cell malignancy characterized by a highly variable clinical course. The behavior of the disease is believed to be influenced by microenvironmental signals that regulate the proliferation and survival of the malignant B-cells. Signals transduced through Toll-like-receptor-9 (TLR9) may play a particularly important role, as they could drive the expansion of a subset of cells that express B-cell receptors reactive with DNA or DNA-containing complexes. Interestingly, leukemic cells from patients with aggressive disease respond more effectively to TLR9 stimulation than their less aggressive counterparts, suggesting that the capacity to respond to TLR9 signals can define distinct prognostic subsets in CLL. The exact mechanism(s) accounting for the variability in the response to TLR9 engagement are still unclear, although important differences have been observed between prognostic groups in terms of downstream signaling events and gene- and miRNA-expression profiles. Understanding the mechanism(s) that underlie the different TLR9 responses should provide further insight in the pathophysiology of CLL and may lead to the identification of novel targets for therapeutic intervention.
Dimitar G Efremov; Riccardo Bomben; Stefania Gobessi; Valter Gattei
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  371-86     Citation Subset:  IM    
Molecular Hematology, International Centre for Genetic Engineering and Biotechnology, Campus A. Buzzati-Traverso, Via E. Ramarini 32, I-00016 Monterotondo Scalo, Rome, Italy.
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MeSH Terms
B-Lymphocytes / pathology
Cell Proliferation / drug effects
Gene Expression Regulation, Leukemic
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*,  immunology
MicroRNAs / metabolism
Oligodeoxyribonucleotides / pharmacology
Signal Transduction / physiology
Toll-Like Receptor 9 / biosynthesis,  physiology*
Reg. No./Substance:
0/MicroRNAs; 0/Oligodeoxyribonucleotides; 0/TLR9 protein, human; 0/Toll-Like Receptor 9

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