| TLR9 regulation by proteolysis: A friend or a foe. | |
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MedLine Citation:
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PMID: 21792872 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Intracellular TLRs sense viral and bacterial nucleic acids from a wide variety of pathogens. Previous studies have shown that TLR9 requires processing for signalling. Following proteolysis, a fragment corresponding to the C-terminal part of TLR9 was shown to bind MyD88 and to induce signalling when cells were stimulated with TLR9 ligands. In this issue of the European Journal of Immunology, a study provides evidence that another proteolytic fragment of TLR9 is generated, different to that described previously, consisting of amino acids 1-723 which mediates inhibition of TLR9 signalling. These results suggest that proteolysis undoubtedly is a key step in TLR9 regulation. |
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Authors:
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Bénédicte Manoury |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of immunology Volume: 41 ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 2142-4 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Institut National de la Santé et la Recherche Médicale, Unité 1013, Paris, France; Université Paris Descartes, Faculté de médecine René Descartes, Paris, France. benedicte.manoury@inserm.fr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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