Document Detail

Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice.
MedLine Citation:
PMID:  23299825     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: TLR4 plays an integrated defense role against HCC carcinogenesis by enhancing the expression and function of DNA repair protein Ku70. Our studies provide novel insight into TLR4 activity in the regulation of HCC tumorigenesis, which may be useful for the prevention of HCC development.
Ziyan Wang; Jun Yan; Heng Lin; Fang Hua; Xiaoxing Wang; Hanzhi Liu; Xiaoxi Lv; Jiaojiao Yu; Su Mi; Jiaping Wang; Zhuo-Wei Hu
Related Documents :
23994465 - Increased cell-mediated immunity in male mice offspring exposed to maternal immune acti...
25024695 - Glutathione and mitochondria.
25087895 - Macrophages in cardiac homeostasis, injury responses and progenitor cell mobilisation.
25050215 - Secretory pathways generating immunosuppressive nkg2d ligands: new targets for therapeu...
25007795 - Copd exacerbation severity and frequency is associated with impaired macrophage efferoc...
24569105 - Mtor limits the recruitment of cd11b+gr1+ly6chigh myeloid-derived suppressor cells in p...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-04-05
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-23     Completed Date:  2013-07-05     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1869-81     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antigens, Nuclear / genetics,  physiology*
Apoptosis / physiology
Carcinoma, Hepatocellular / pathology,  physiopathology,  prevention & control*
Cell Transformation, Neoplastic* / chemically induced
DNA Repair / genetics,  physiology
DNA-Binding Proteins / genetics,  physiology*
Diethylnitrosamine / adverse effects
Disease Models, Animal
Disease Progression*
Gene Expression Regulation, Neoplastic / physiology*
Liver Neoplasms / pathology,  physiopathology,  prevention & control*
Mice, Inbred C3H
Mice, Mutant Strains
Mutation / genetics
Signal Transduction / physiology
Toll-Like Receptor 4 / genetics,  physiology*
Reg. No./Substance:
0/Antigens, Nuclear; 0/DNA-Binding Proteins; 0/Ku autoantigen; 0/Tlr4 protein, mouse; 0/Toll-Like Receptor 4; 3IQ78TTX1A/Diethylnitrosamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Biomarkers and predictors of restorative therapy effects after stroke.
Next Document:  Rectal cancer : when is the local recurrence risk low enough to refrain from the aim to prevent it?