Document Detail


Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice.
MedLine Citation:
PMID:  23299825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: TLR4 plays an integrated defense role against HCC carcinogenesis by enhancing the expression and function of DNA repair protein Ku70. Our studies provide novel insight into TLR4 activity in the regulation of HCC tumorigenesis, which may be useful for the prevention of HCC development.
Authors:
Ziyan Wang; Jun Yan; Heng Lin; Fang Hua; Xiaoxing Wang; Hanzhi Liu; Xiaoxi Lv; Jiaojiao Yu; Su Mi; Jiaping Wang; Zhuo-Wei Hu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-04-05
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-23     Completed Date:  2013-07-05     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1869-81     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, Nuclear / genetics,  physiology*
Apoptosis / physiology
Carcinoma, Hepatocellular / pathology,  physiopathology,  prevention & control*
Cell Transformation, Neoplastic* / chemically induced
DNA Repair / genetics,  physiology
DNA-Binding Proteins / genetics,  physiology*
Diethylnitrosamine / adverse effects
Disease Models, Animal
Disease Progression*
Female
Gene Expression Regulation, Neoplastic / physiology*
Liver Neoplasms / pathology,  physiopathology,  prevention & control*
Male
Mice
Mice, Inbred C3H
Mice, Mutant Strains
Mutation / genetics
Signal Transduction / physiology
Toll-Like Receptor 4 / genetics,  physiology*
Chemical
Reg. No./Substance:
0/Antigens, Nuclear; 0/DNA-Binding Proteins; 0/Ku autoantigen; 0/Tlr4 protein, mouse; 0/Toll-Like Receptor 4; 3IQ78TTX1A/Diethylnitrosamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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