| TLR-4 gene polymorphisms: evidence for protection against type 2 diabetes but not for diabetes-associated ischaemic heart disease. | |
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MedLine Citation:
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PMID: 21628510 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Several factors either predisposing or protecting from the onset of diabetes mellitus type 2 (DM2) have been proposed. Two specific polymorphisms of Toll-like receptor-4 (Asp299Gly and Thr399Ile) have been recently identified either as candidate protector genes against DM2 and associated neuropathy or risk alleles for the manifestation of diabetic retinopathy. The impact of these alleles on the risk for ischaemic heart disease (IHD) is controversial while their role in diabetes-associated IHD has never been studied. Design and Methods: In order to clarify the potential impact of TLR-4 polymorphisms on the predisposition for DM2 as well as on diabetes-related IHD vulnerability, the distribution of the mutant TLR-4 Asp299Gly and Thr399Ile alleles, in 286 DM2 patients and 413 non-DM2 controls, with or without IHD, was examined. RESULTS: Mutant alleles were detected predominantly in non-diabetic individuals: 79/413 vs 15/286, in DM2 patients (P<0.0001). The rates of positivity for mutant alleles were similar between diabetic patients with or without IHD (7/142 vs 8/144, P>0.1) whereas they proved different between non-diabetic individuals with or without IHD (39/145 vs 40/268, P=0.004). Following multivariate analysis, only the difference between diabetic and non-diabetic subjects, with regard to TLR-4 mutations, remained significant (P=0.04). CONCLUSIONS: Mutant TLR-4 alleles, confer protection against DM2. Their presence, however, does not seem to play any role, protective or aggravating, in the manifestation of IHD either in diabetic or non-diabetic individuals. |
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Authors:
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Anastassios C Manolakis; Andreas N Kapsoritakis; Elisavet K Tiaka; Andreas Sidiropoulos; Aggeliki Gerovassili; Maria Satra; Dimitra Vamvakopoulou; Fotios Tsiopoulos; Nikolaos Papanas; Ioannis Skoularigis; Spyros P Potamianos; Nikolaos Vamvakopoulos |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-31 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: - ISSN: 1479-683X ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-6-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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A Manolakis, Department of Gastroenterology, School of Medicine, University of Thessaly, Larissa, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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