Document Detail


TLC identification adn GLC determination of meperidine and its metabolites in biological fluids.
MedLine Citation:
PMID:  7241346     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Procedures were developed for TLC identification and GLC determination of meperidine and its metabolites, i.e., p-hydroxymeperidine, normeperidine, and meperidinic and normeperidinic acids. Meperidine, p-hydroxymeperidine, and normeperidine were extracted with ether from biological fluids at pH 10, whereas meperidinic and normeperidinic acids and conjugated metabolites remained in the aqueous phase. The residue, upon evaporation of the extract to dryness, was derivatized with trifluoroacetic anhydride and gas chromatographed. Total (free and conjugated) meperidinic and normeperidinic acids in the aqueous phase were converted and determined as meperidine and normeperidine, respectively. A preliminary result of urinary disposition of meperidine and its metabolites in the rat is presented. The identity of these metabolites was confirmed with GLC-mass spectrometry.
Authors:
S Y Yeh; H A Krebs
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  70     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-08-20     Completed Date:  1981-08-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  482-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biotransformation
Chromatography, Gas / methods
Chromatography, Thin Layer / methods
Male
Meperidine / analogs & derivatives,  analysis*
Rats
Chemical
Reg. No./Substance:
4220-06-8/4-hydroxymeperidine; 57-42-1/Meperidine; 77-17-8/normeperidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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