| TLC identification adn GLC determination of meperidine and its metabolites in biological fluids. | |
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MedLine Citation:
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PMID: 7241346 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Procedures were developed for TLC identification and GLC determination of meperidine and its metabolites, i.e., p-hydroxymeperidine, normeperidine, and meperidinic and normeperidinic acids. Meperidine, p-hydroxymeperidine, and normeperidine were extracted with ether from biological fluids at pH 10, whereas meperidinic and normeperidinic acids and conjugated metabolites remained in the aqueous phase. The residue, upon evaporation of the extract to dryness, was derivatized with trifluoroacetic anhydride and gas chromatographed. Total (free and conjugated) meperidinic and normeperidinic acids in the aqueous phase were converted and determined as meperidine and normeperidine, respectively. A preliminary result of urinary disposition of meperidine and its metabolites in the rat is presented. The identity of these metabolites was confirmed with GLC-mass spectrometry. |
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Authors:
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S Y Yeh; H A Krebs |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 70 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1981 May |
Date Detail:
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Created Date: 1981-08-20 Completed Date: 1981-08-20 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 482-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biotransformation Chromatography, Gas / methods Chromatography, Thin Layer / methods Male Meperidine / analogs & derivatives, analysis* Rats |
| Chemical | |
Reg. No./Substance:
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4220-06-8/4-hydroxymeperidine; 57-42-1/Meperidine; 77-17-8/normeperidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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