Document Detail

TIMI myocardial perfusion frame count: a new method to assess myocardial perfusion and its predictive value for short-term prognosis.
MedLine Citation:
PMID:  19960517     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We sought to develop a new quantitative method to evaluate the degree of myocardial perfusion.
BACKGROUND: Currently available methods for assessing myocardial perfusion, both TIMI myocardial perfusion grading (TMPG) and myocardial blush grading (MBG), are subjective.
METHODS: TIMI Myocardial Perfusion Frame Count (TMPFC), an objective method that measures the filling and clearance of contrast in the myocardium using cine-angiographic frame-counting, was developed to quantify myocardial perfusion. Myocardial perfusion of 45 normal coronary arteries in 15 patients, and 137 culprit arteries in 137 patients immediately after primary angioplasty, was successfully assessed with TMPFC.
RESULTS: The mean TMPFC in the normal arteries was 83.47 +/- 17.96 frames (95% CI: 78.07 frames <or= TMPFC <or= 88.86 frames). Therefore, TMPFC < 90 frames, a value representing the upper bound of the 95% CI for the TMPFC observed in normal arteries, was defined as normal myocardial perfusion. In 137 culprit arteries, the mean TMPFC values after primary angioplasty for the right coronary artery (RCA), left anterior descending artery (LAD), and left circumflex artery (LCX) were 141 +/- 82.6, 112 +/- 80.3, and 102 +/- 37.5 frames, respectively. Patients with suboptimal myocardial perfusion (ex: TMPG <or= 2 or MBG <or= 2 grade) had higher levels of TMPFC. Furthermore, multivariate analysis shows that the TMPFC was an independent predictor for 30-day (P = 0.0261) and 6-month incidence of MACE (P = 0.0207).
CONCLUSIONS: TMPFC is a quantitative index for the assessment of myocardial perfusion; it allows quantification of TMPG and may serve as a discerning tool to predict prognosis in patients undergoing primary angioplasty.
Song Ding; Jun Pu; Zhi-qing Qiao; Peiren Shan; Wei Song; Yongping Du; Jie-Yan Shen; Shu-xuan Jin; Yu Sun; Long Shen; Yean-leng Lim; Ben He
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  75     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-30     Completed Date:  2010-06-18     Revised Date:  2011-03-21    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  722-32     Citation Subset:  IM    
Copyright Information:
(c) 2009 Wiley-Liss, Inc.
Department of Cardiology, Shanghai Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
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MeSH Terms
Angioplasty, Balloon, Coronary* / adverse effects
Coronary Angiography*
Coronary Circulation*
Databases as Topic
Middle Aged
Myocardial Infarction / physiopathology,  radiography*,  therapy*
Myocardial Perfusion Imaging / methods*
Observer Variation
Predictive Value of Tests
Prospective Studies
Reproducibility of Results
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Comment In:
Catheter Cardiovasc Interv. 2010 Apr 1;75(5):733-4   [PMID:  20333673 ]
Catheter Cardiovasc Interv. 2010 Dec 1;76(7):1073-5   [PMID:  20518001 ]
Catheter Cardiovasc Interv. 2011 Feb 15;77(3):459   [PMID:  20517992 ]

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