| TIM1 haplotype may control the disease progression to AIDS in a HIV-1-infected female cohort in Thailand. | |
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MedLine Citation:
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PMID: 20479636 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate association of TIM1 sequence variations with HIV/AIDS progression. INTRODUCTION:: HIV-1 infected individuals have wide variations in disease progression including AIDS. T cell immunoglobulin and mucin 1 (TIM1) is a cell surface protein involved in the regulation of Th1/Th2 immune response. MATERIALS AND METHODS: We sequenced the highly polymorphic exon 4 of TIM1 from 246 individuals of HIV-1 infected Thai female cohort to determine their TIM1 haplotypes. Associations of TIM1 haplotypes with baseline clinical data (sero-status, plasma viral load, CD4 cell count, and symptomatic AIDS) and survival status during 3 years of follow-up were evaluated. RESULTS: Seven TIM1 haplotypes, D3-A, D4, D3-C, D1, W-A, W-C, and D3-C*, were found in the cohort. Patients possessing the D3-A haplotype showed trends towards higher CD4 cell count (P = 0.06) and lower proportion of AIDS-related symptoms (P = 0.022) than the other patients at the baseline. Kaplan-Meier analysis demonstrated that patients carrying the D3-A haplotype had a better survival rates (P = 0.019) than the others. D3-A haplotypes was tightly linked to the lower expression levels of TIM1. CONCLUSION: TIM1 D3-A haplotype is associated with the delay of disease progression to AIDS in the HIV-1 infected Thai females. |
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Authors:
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Nuanjun Wichukchinda; Toshiaki Nakajima; Nongluk Saipradit; Emi E Nakayama; Hitoshi Ohtani; Archawin Rojanawiwat; Panita Pathipvanich; Koya Ariyoshi; Pathom Sawanpanyalert; Tatsuo Shioda; Akinori Kimura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: AIDS (London, England) Volume: 24 ISSN: 1473-5571 ISO Abbreviation: AIDS Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-30 Completed Date: 2010-08-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710219 Medline TA: AIDS Country: England |
Other Details:
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Languages: eng Pagination: 1625-31 Citation Subset: IM; X |
Affiliation:
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National institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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genetics,
immunology CD4 Lymphocyte Count Disease Progression Female Follow-Up Studies Genetic Predisposition to Disease Genotype HIV Infections / genetics*, immunology, metabolism, virology HIV-1* Haplotypes Humans Membrane Glycoproteins / genetics*, metabolism Prognosis Receptors, Virus / genetics*, metabolism Survival Analysis Viral Load |
| Chemical | |
Reg. No./Substance:
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0/HAVCR1 protein, human; 0/Membrane Glycoproteins; 0/Receptors, Virus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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