Document Detail


T(H)2 adjuvants: implications for food allergy.
MedLine Citation:
PMID:  18539190     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A persistent question for immunologists studying allergic disease has been to define the characteristics of a molecule that make it allergenic. There has been substantial progress elucidating mechanisms of innate priming of T(H)2 immunity in the past several years. These accumulating data demonstrate that T(H)2 immunity is actively induced by an array of molecules, many of which were first discovered in the context of antihelminthic immune responses. Similar intrinsic or associated activities are now known to account for the T(H)2 immunogenicity of some allergens, and may prove to play a role for many more. In this review, we discuss what has been discovered regarding molecules that induce innate immune activation and the pathways that promote T(H)2-polarized immune responses generally, and specifically what role these mechanisms may play in food allergy from models of food allergy and the study of T(H)2 gastrointestinal adjuvants.
Authors:
M Cecilia Berin; Wayne G Shreffler
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  121     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-09     Completed Date:  2008-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1311-20; quiz 1321-2     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Division of Allergy and Immunology, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic*
Allergens / immunology*
Animals
Antigen Presentation / immunology
Cell Differentiation / immunology
Food Hypersensitivity / immunology*
Humans
Lymphocyte Activation / immunology
T-Lymphocyte Subsets / cytology,  immunology
Th2 Cells / cytology,  immunology*
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Allergens

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