Document Detail


TGM2 and implications for human disease: role of alternative splicing.
MedLine Citation:
PMID:  23276939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alternative splicing is an important mechanism for modulating gene function that accounts for a considerable proportion of proteomic complexity in higher eukaryotes. Alternative splicing is often tightly regulated in a cell-type- or developmental-stage- specific manner and can cause a single gene to have multiple functions. Human Tissue transglutaminase (TGM2) is a multifunctional enzyme with transglutaminase crosslinking (TGase), G protein signaling and kinase activities that are postulated to play a role in many disease states. TGM2 mRNA is regulated by alternative splicing, producing C-terminal truncated forms of TGM2 that are predicted to have distinct biochemical properties and biological functions. In this review, we will discuss how alternatively spliced forms of TGM2 could modulate its roles in cancer, neurodegeneration, inflammation and wound healing.
Authors:
Thung-S Lai; Charles S Greenberg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  504-19     Citation Subset:  IM    
Affiliation:
Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA.
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MeSH Terms
Descriptor/Qualifier:
Alternative Splicing*
Animals
Autoimmunity / physiology
Calcium / pharmacology
Cell Adhesion / physiology
Epithelial-Mesenchymal Transition
Guanosine Triphosphate / pharmacology
Humans
Models, Molecular
Neurodegenerative Diseases / physiopathology
Transglutaminases / antagonists & inhibitors,  chemistry,  genetics*,  metabolism
Wound Healing / physiology
Grant Support
ID/Acronym/Agency:
HL072184/HL/NHLBI NIH HHS; NS050541/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
7440-70-2/Calcium; 86-01-1/Guanosine Triphosphate; EC 2.3.2.13/Transglutaminases; EC 2.3.2.13/tissue transglutaminase 2, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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