| TGFbeta signalling: a complex web in cancer progression. | |
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MedLine Citation:
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PMID: 20495575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distortion of growth factor signalling is the most important prerequisite in tumour progression. Transforming growth factor-beta (TGFbeta) signalling regulates tumour progression by a tumour cell-autonomous mechanism or through tumour-stroma interaction, and has either a tumour-suppressing or tumour-promoting function depending on cellular context. Such inherent complexity of TGFbeta signalling results in arduous, but promising, assignments for developing therapeutic strategies against malignant tumours. As numerous cellular context-dependent factors tightly maintain the balance of TGFbeta signalling and contribute to the regulation of TGFbeta-induced cell responses, in this Review we discuss how they maintain the balance of TGFbeta signalling and how their collapse leads to tumour progression. |
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Authors:
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Hiroaki Ikushima; Kohei Miyazono |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature reviews. Cancer Volume: 10 ISSN: 1474-1768 ISO Abbreviation: Nat. Rev. Cancer Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101124168 Medline TA: Nat Rev Cancer Country: England |
Other Details:
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Languages: eng Pagination: 415-24 Citation Subset: IM |
Affiliation:
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Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Progression* Humans Neoplasm Metastasis Neoplasms / blood supply, genetics, metabolism*, pathology* Neovascularization, Pathologic Signal Transduction* Transforming Growth Factor beta / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Transforming Growth Factor beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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