Document Detail


TGFbeta as a potential mediator of progesterone action in the mammary gland of pregnancy.
MedLine Citation:
PMID:  18027075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The molecular mechanisms controlling the onset of copious milk secretion are only now beginning to be elucidated. We have known for nearly four decades that progesterone suppresses milk secretion during pregnancy, and that the fall in progesterone near parturition is necessary for secretory activation. Similarly, we've known for 15 years that transforming growth factor beta (TGFbeta) also suppresses milk secretion. Yet no formal link between the two has ever been established. This work aims to review the evidence for and against a link between progesterone and TGFbeta, raise unanswered questions, and to propose further lines of research.
Authors:
Jenifer Monks
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2007-11-20
Journal Detail:
Title:  Journal of mammary gland biology and neoplasia     Volume:  12     ISSN:  1083-3021     ISO Abbreviation:  J Mammary Gland Biol Neoplasia     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-28     Completed Date:  2008-02-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9601804     Medline TA:  J Mammary Gland Biol Neoplasia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  249-57     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, MS 8309, University of Colorado Health Sciences, Anschutz Medical Campus, P.O. Box 6511, 12800 E. 19th Avenue, Aurora, CO 80045, USA. Jenifer.Monks@UCHSC.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Humans
Mammary Glands, Animal / metabolism*,  secretion
Mammary Glands, Human / metabolism*,  secretion
Pregnancy
Progesterone / metabolism*,  secretion
Protein Isoforms / classification,  metabolism
Signal Transduction
Transforming Growth Factor beta / classification,  metabolism*
Grant Support
ID/Acronym/Agency:
P01-HD38129/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Protein Isoforms; 0/Transforming Growth Factor beta; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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