| TGF-beta promotes thyroid epithelial cell hyperplasia and fibrosis in IFN-gamma-deficient NOD.H-2h4 mice. | |
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MedLine Citation:
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PMID: 18641364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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IFN-gamma(-/-)NOD.H-2h4 mice given 0.05% NaI in their water develop severe thyroid epithelial cell (thyrocyte) hyperplasia and proliferation (TEC H/P) and fibrosis. Proliferating thyrocytes of IFN-gamma(-/-) mice with TEC H/P produce TGF-beta as demonstrated by immunohistochemical staining and in situ hybridization. Strong expression of activating phosphorylated Smad-2/3 and weak expression of inhibitory Smad-7 by proliferating thyrocytes correlate with the severity of TEC H/P. Splenocytes from IFN-gamma(-/-) mice with severe TEC H/P transfer severe TEC H/P to IFN-gamma(-/-)NOD.H-2h4.SCID mice. Mice given anti-TGF-beta had markedly reduced thyrocyte proliferation and decreased fibrosis compared with mouse Ig-treated controls, suggesting that TGF-beta plays an important role in development of TEC H/P induced by activated splenocytes. Moreover, transgenic IFN-gamma(-/-)NOD.H-2h4 mice expressing TGF-beta on thyrocytes all develop fibrosis and moderate to severe TEC H/P with accelerated kinetics, directly demonstrating a role for TGF-beta in severe TEC H/P and fibrosis. |
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Authors:
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Shiguang Yu; Gordon C Sharp; Helen Braley-Mullen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 181 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-21 Completed Date: 2008-08-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 2238-45 Citation Subset: AIM; IM |
Affiliation:
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Department of Veterans Affairs Research Service, Columbia, MO 65212, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies / immunology Cell Proliferation Epithelial Cells / cytology, metabolism* Fibrosis / genetics, metabolism, pathology Interferon-gamma / deficiency*, genetics, metabolism* Mice Mice, Inbred NOD Mice, Knockout Phosphorylation Protein-Serine-Threonine Kinases / metabolism Receptors, Transforming Growth Factor beta / metabolism Smad2 Protein / metabolism Smad3 Protein / metabolism Spleen / immunology, metabolism Thymus Hyperplasia / genetics, metabolism*, pathology* Transforming Growth Factor beta / genetics, immunology, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Receptors, Transforming Growth Factor beta; 0/Smad2 Protein; 0/Smad2 protein, mouse; 0/Smad3 Protein; 0/Smad3 protein, mouse; 0/Transforming Growth Factor beta; 82115-62-6/Interferon-gamma; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.30/transforming growth factor-beta type II receptor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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