Document Detail

TGF-beta in uveal melanoma.
MedLine Citation:
PMID:  11170298     Owner:  NLM     Status:  MEDLINE    
Uveal melanoma is the most common primary ocular cancer among adults and patients with distant metastases seldom survive longer than a year. Melanomas of the eye have the advantage of growing in the special environment of an immune privileged site and it has long been shown, that the special immunosuppressive properties of the intraocular microenvironment are strongly mediated by cytokines, especially transforming growth factor-beta (TGF-beta). Here, we sought to investigate the presence of TGF-beta in surgically removed uveal melanoma specimens using immunohistochemical methods to verify possible autocrine mechanisms. Immunocytochemistry for pan-TGF-beta and TGF-beta(2) was performed on 13 melanoma specimens using an alkaline phosphatase labeling procedure. Melanocytic origin of the tumors was confirmed by HMB-45 staining. All tissue samples exhibited positive staining using either pan-TGF-beta or TGF-beta(2) antibody regardless of cell-type, size of the tumor, or tumor location. The intensity of staining did not vary significantly within a given tumor. All tumors stained positive against the HMB-45 antibody. Many cytokines have been found to act on melanoma tumors. The presence of the TGF-beta(2) isoform in all specimens points to progressive tumor-growth as has been shown for melanomas of the skin. Based on our immunohistochemical findings and the immunosuppressive properties of TGF-beta, we suppose that ocular melanomas should be able to create their own immunosuppressive environment even in the uvea, which might be a non-privileged site.
P Esser; S Grisanti; K Bartz-Schmidt
Related Documents :
8982608 - The use of two-dimensional gel electrophoresis in studies on the role of cytoskeletal p...
15292388 - Associations among beta-trcp, an e3 ubiquitin ligase receptor, beta-catenin, and nf-kap...
8871928 - Expression of the cd44 cell adhesion molecule in urinary bladder transitional cell carc...
15696118 - Kidney-specific cadherin, a specific marker for the distal portion of the nephron and r...
9686608 - Bcl-2-mediated inhibition of apoptosis prevents immunogenicity and restores tumorigenic...
22198428 - Number of circulating endothelial progenitor cells and intratumoral microvessel density...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Microscopy research and technique     Volume:  52     ISSN:  1059-910X     ISO Abbreviation:  Microsc. Res. Tech.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203012     Medline TA:  Microsc Res Tech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  396-400     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Wiley-Liss, Inc.
University Eye Clinic Köln (Cologne), D-50931 Köln, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Immune Tolerance
Melanoma / immunology,  metabolism*
Middle Aged
Transforming Growth Factor beta / metabolism*
Uveal Neoplasms / immunology,  metabolism*
Reg. No./Substance:
0/Transforming Growth Factor beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Role of TGF-beta in immune-evasion of cancer.
Next Document:  Malignant glioma biology: role for TGF-beta in growth, motility, angiogenesis, and immune escape.