|TGF-beta control of rat thyroid follicular cells differentiation.|
|PMID: 12972178 Owner: NLM Status: MEDLINE|
|TGF-beta1 is a potent inhibitor of growth and DNA synthesis in thyroid cells. It has also been shown that TGF-beta1 inhibits thyrocyte function. The functional inhibition is represented by a downregulation of thyroid specific genes, such as Na(+)/I(-) symporter (NIS), thyroglobulin (TG) and thyroperoxidase (TPO). The transcriptional control of these genes is mediated by thyroid-specific transcription factors: thyroid transcription factor-1 (TTF-1) and PAX-8. It has been shown that Smad proteins play a pivotal role in the intracellular signal transduction of the TGF-beta family members. In this paper, the functional relevance of Smad4, in the control of thyroid differentiation genes and thyroid-specific transcription factors, has been investigated. The data obtained provides, for the first time, evidence that D.N. Smad4-100T is capable of blocking TGF-beta1 action in the regulation of thyroid-specific genes expression. Such action is possible by blocking nuclear translocation of Smad4 and Smad2.|
|Arianna Nicolussi; Sonia D'Inzeo; Maria Santulli; Giulia Colletta; Anna Coppa|
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|Type: Journal Article; Research Support, Non-U.S. Gov't|
|Title: Molecular and cellular endocrinology Volume: 207 ISSN: 0303-7207 ISO Abbreviation: Mol. Cell. Endocrinol. Publication Date: 2003 Sep|
|Created Date: 2003-09-15 Completed Date: 2004-05-20 Revised Date: 2006-11-15|
Medline Journal Info:
|Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: Ireland|
|Languages: eng Pagination: 1-11 Citation Subset: IM|
|Department of Experimental Medicine and Pathology, University 'La Sapienza', v.le Regina Elena 324, 00161, Rome, Italy|
|APA/MLA Format Download EndNote Download BibTex|
Autoantigens / genetics, physiology
Cell Differentiation / drug effects*
Cysteine Endopeptidases / genetics, metabolism
DNA-Binding Proteins / genetics, metabolism, physiology
Gene Expression Regulation / drug effects
Genetic Vectors / genetics
Iodide Peroxidase / genetics, physiology
Iron-Binding Proteins / genetics, physiology
Luciferases / genetics, metabolism
Mutation / genetics
Nuclear Proteins / genetics, metabolism
Paired Box Transcription Factors
Recombinant Fusion Proteins / genetics, metabolism
Signal Transduction / physiology
Symporters / genetics, physiology
Thyroid Gland / cytology, drug effects*
Thyrotropin / pharmacology
Trans-Activators / genetics, metabolism, physiology
Transcription Factors / genetics, metabolism
Transforming Growth Factor beta / pharmacology*, physiology
Transforming Growth Factor beta1
|0/Autoantigens; 0/DNA-Binding Proteins; 0/Iron-Binding Proteins; 0/Madh2 protein, rat; 0/Madh4 protein, rat; 0/Nuclear Proteins; 0/Paired Box Transcription Factors; 0/Pax8 protein, rat; 0/Recombinant Fusion Proteins; 0/Smad2 Protein; 0/Smad4 Protein; 0/Symporters; 0/TGFB1 protein, human; 0/Tgfb1 protein, rat; 0/Trans-Activators; 0/Transcription Factors; 0/Transforming Growth Factor beta; 0/Transforming Growth Factor beta1; 0/sodium-iodide symporter; 0/thyroid nuclear factor 1; 9002-71-5/Thyrotropin; EC 18.104.22.168/TPO protein, human; EC 22.214.171.124/Iodide Peroxidase; EC 1.13.12.-/Luciferases; EC 3.4.22.-/Cysteine Endopeptidases; EC 3.4.22.-/cysteine proteinase I|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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