| TGF-β Function in Immune Suppression. | |
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MedLine Citation:
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PMID: 20680806 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Transforming growth factor-β (TGF-β) has been shown to play an essential role in establishing immunological tolerance, yet recent studies have revealed the pro-inflammatory roles of TGF-β in inflammatory responses. TGF-β induces Foxp3-positive regulatory T cells (iTregs), while in the presence of IL-6, it induces pathogenic IL-17 producing Th17 cells. TGF-β inhibits the proliferation of T cells as well as cytokine production via Foxp3-dependent and independent mechanisms. On the one hand, little is known about molecular mechanisms involved in immune suppression via TGF-β; however, recent studies suggest that Smad2 as well as Smad3 play essential roles in Foxp3 induction and cytokine suppression, whereas Th17 differentiation is promoted via the Smad-independent pathway. Mutual suppression of signaling between TGF-β and inflammatory cytokines has been shown to be necessary for the balance of immunity and tolerance. |
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Authors:
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Akihiko Yoshimura; Go Muto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current topics in microbiology and immunology Volume: 350 ISSN: 0070-217X ISO Abbreviation: Curr. Top. Microbiol. Immunol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-04-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0110513 Medline TA: Curr Top Microbiol Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 127-47 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan, yoshimura@a6.keio.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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