| TGF-beta 1 Codon 10 Polymorphism is Associated with Cerebral SVD. | |
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MedLine Citation:
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PMID: 22030425 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: To clarify the role of inflammation in the pathogenesis of cerebral small vessel disease (SVD), we investigated whether the gene encoding transforming growth factor-beta 1(TGF-beta 1) is a risk factor for cerebral SVD as a whole, and for two different SVD subtypes. Methods: TGF-beta 1 codon10 (T+29C) genotype was determined in 441 Chinese patients (313 male and 128 female) with cerebral SVD and 450 control subjects (326 male and 124 female). Cerebral SVD patients were retrospectively classified into two groups based on neuroimaging findings: lacunar infarction group with 112 patients and ischaemic leukoaraiosis group with 329 patients. Results: Subjects carrying TT homozygote were susceptible to cerebral SVD [adjusted odds ratio (OR) =1.44, 95% confidence interval (CI), 1.05-1.98; P=0.026]. Further analysis of SVD subtypes revealed a moderate association with the ischaemic leukoaraiosis group [OR= 1.60, 95% CI, 1.14-2.25; P=0.007]. Conclusions: Codon 10 of TGF-beta 1 might be a risk factor for SVD, specifically in ischaemic leukoaraiosis phenotype. |
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Authors:
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Hong-Miao Tao; Guo-Zhong Chen; Xiao-Dong Lu; Xiao-Gang Hu; Gan-Ping Chen; Bei Shao |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques Volume: 38 ISSN: 0317-1671 ISO Abbreviation: Can J Neurol Sci Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0415227 Medline TA: Can J Neurol Sci Country: Canada |
Other Details:
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Languages: eng Pagination: 869-73 Citation Subset: IM |
Affiliation:
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School of Medicine, Jinhua College of Profession & Technology. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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