Document Detail


TGF-beta 1 codon 10 polymorphism is associated with cerebral SVD.
MedLine Citation:
PMID:  22030425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: To clarify the role of inflammation in the pathogenesis of cerebral small vessel disease (SVD), we investigated whether the gene encoding transforming growth factor-beta 1(TGF-beta 1) is a risk factor for cerebral SVD as a whole, and for two different SVD subtypes.
METHODS: TGF-beta 1 codon10 (T+29C) genotype was determined in 441 Chinese patients (313 male and 128 female) with cerebral SVD and 450 control subjects (326 male and 124 female). Cerebral SVD patients were retrospectively classified into two groups based on neuroimaging findings: lacunar infarction group with 112 patients and ischaemic leukoaraiosis group with 329 patients.
RESULTS: Subjects carrying TT homozygote were susceptible to cerebral SVD [adjusted odds ratio (OR) =1.44, 95% confidence interval (CI), 1.05-1.98; P=0.026]. Further analysis of SVD subtypes revealed a moderate association with the ischaemic leukoaraiosis group [OR= 1.60, 95% CI, 1.14-2.25; P=0.007].
CONCLUSIONS: Codon 10 of TGF-beta 1 might be a risk factor for SVD, specifically in ischaemic leukoaraiosis phenotype.
Authors:
Hong-miao Tao; Guo-zhong Chen; Xiao-dong Lu; Xiao-gang Hu; Gan-ping Chen; Bei Shao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques     Volume:  38     ISSN:  0317-1671     ISO Abbreviation:  Can J Neurol Sci     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-27     Completed Date:  2012-01-19     Revised Date:  2013-03-11    
Medline Journal Info:
Nlm Unique ID:  0415227     Medline TA:  Can J Neurol Sci     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  869-73     Citation Subset:  IM    
Affiliation:
School of Medicine, Jinhua College of Profession & Technology, Zhejiang Province, The People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Aged
Cerebral Small Vessel Diseases / genetics*
Confidence Intervals
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease / genetics*
Genotype
Humans
Male
Middle Aged
Odds Ratio
Polymorphism, Genetic / genetics*
Polymorphism, Single Nucleotide / genetics*
Transforming Growth Factor beta1 / genetics*
Chemical
Reg. No./Substance:
0/TGFB1 protein, human; 0/Transforming Growth Factor beta1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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