| TGF-b signaling in cartilage homeostasis and osteoarthritis. | |
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MedLine Citation:
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PMID: 22202058 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Healthy cartilage is maintained by a delicate balance between the anabolic and catabolic activities of articular chondrocytes. This involves actions of numerous cytokines and growth factors that regulate the synthesis and degradation of extracellular matrix components which maintain the functional integrity of the joint. An imbalance between the activities of these anabolic and catabolic factors leads to cartilage degradation resulting in osteoarthritis (OA), a chronic degenerative joint disorder characterized by destruction of articular cartilage, alterations of subchondral bone and synovial fibrosis. Among the cytokines and growth factors that have been studied in the context of cartilage homeostasis and OA, transforming growth factor-beta-b (TGF-b) has emerged as an important molecule that plays a critical role in the development, growth, maintenance and repair of articular cartilage. Deregulation of its signaling and responses has been shown to be involved in OA. Several components of the TGF-b pathway, including extracellular, cell surface and intracellular molecules, display altered expression or action in OA. In this review, we discuss the regulatory mechanisms of TGF-b signaling and link these mechanisms to cartilage function, highlighting the important role of TGF-b in maintaining cartilage function and integrity. We also summarize the alterations in the molecular events of TGF-b signaling and responses that may contribute to OA progression and discuss the potential of targeting the TGF-b signaling pathway for the development of novel therapies for OA. |
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Authors:
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Kenneth W Finnson; Yoon Chi; George Bou-Gharios; Andrew Leask; Anie Philip |
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Publication Detail:
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Type: Journal Article Date: 2012-01-01 |
Journal Detail:
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Title: Frontiers in bioscience (Scholar edition) Volume: 4 ISSN: 1945-0524 ISO Abbreviation: Front Biosci (Schol Ed) Publication Date: 2012 |
Date Detail:
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Created Date: 2011-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101485241 Medline TA: Front Biosci (Schol Ed) Country: United States |
Other Details:
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Languages: eng Pagination: 251-68 Citation Subset: IM |
Affiliation:
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Division of Plastic Surgery, Department of Surgery, Montreal General Hospital, McGill University, Montreal, QC, H3G 1A4 Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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