Document Detail

TGF-β-associated miR-27a inhibits dendritic cell-mediated differentiation of Th1 and Th17 cells by TAB3, p38 MAPK, MAP2K4 and MAP2K7.
MedLine Citation:
PMID:  23034448     Owner:  NLM     Status:  Publisher    
The alterations induced in dendritic cells (DCs) in the cancer microenvironment have not been extensively explored. We found that the tumor-associated factor TGF-β may selectively upregulate the expression of miR-27a via the SP1 transcription factor. Importantly, miR-27a altered the activity of NF-κB and MAPKs (mitogen-activated protein kinases) p38, JNK (c-Jun N-terminal kinases) and ERK (extracellular signal-regulated kinase 1/2). It influences the production of proinflammatory cytokines by targeting TAB3, p38 MAPK, MAP2K4 and MAP2K7. As a consequence, miR-27a hampered the DC-mediated differentiation of Th1 and Th17 cells in vitro and in vivo, but it promoted the DC-mediated accumulation of Tr1 (CD4(+)IL-10(+)) and Treg (CD4(+)CD25(+)Foxp3(+)) cells in vivo. The repeated infusion of miR-27a-engineered DCs into tumor tissues accelerated tumor growth, indicating that miR-27a is a potential target for tumor immunotherapy.Genes and Immunity advance online publication, 4 October 2012; doi:10.1038/gene.2012.45.
S Min; L Li; M Zhang; Y Zhang; X Liang; Y Xie; Q He; Y Li; J Sun; Q Liu; X Jiang; Y Zhang; Y Che; R Yang
Related Documents :
6092068 - Nucleoside diphosphate kinase from brain. purification and effect on microtubule assemb...
25377478 - Oxygen and temperature dependent expression of survival protein kinases in crucian carp...
23498918 - Discovery of n-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-m...
19400808 - Stimulation of the potassium sensor kdpd kinase activity by interaction with the phosph...
10593908 - A point mutation in a plant calmodulin is responsible for its inhibition of nitric-oxid...
15735648 - Alternative p38 activation pathway mediated by t cell receptor-proximal tyrosine kinases.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-04
Journal Detail:
Title:  Genes and immunity     Volume:  -     ISSN:  1476-5470     ISO Abbreviation:  Genes Immun.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100953417     Medline TA:  Genes Immun     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Immunology, Nankai University School of Medicine, Tianjin, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bioelectrode-based approach for enhancing nitrate and nitrite removal and electricity generation fro...
Next Document:  Antioxidant properties and cytotoxic effects on human cancer cell lines of aqueous fermented and lip...