| TGF-β-associated miR-27a inhibits dendritic cell-mediated differentiation of Th1 and Th17 cells by TAB3, p38 MAPK, MAP2K4 and MAP2K7. | |
| | |
MedLine Citation:
|
PMID: 23034448 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The alterations induced in dendritic cells (DCs) in the cancer microenvironment have not been extensively explored. We found that the tumor-associated factor TGF-β may selectively upregulate the expression of miR-27a via the SP1 transcription factor. Importantly, miR-27a altered the activity of NF-κB and MAPKs (mitogen-activated protein kinases) p38, JNK (c-Jun N-terminal kinases) and ERK (extracellular signal-regulated kinase 1/2). It influences the production of proinflammatory cytokines by targeting TAB3, p38 MAPK, MAP2K4 and MAP2K7. As a consequence, miR-27a hampered the DC-mediated differentiation of Th1 and Th17 cells in vitro and in vivo, but it promoted the DC-mediated accumulation of Tr1 (CD4(+)IL-10(+)) and Treg (CD4(+)CD25(+)Foxp3(+)) cells in vivo. The repeated infusion of miR-27a-engineered DCs into tumor tissues accelerated tumor growth, indicating that miR-27a is a potential target for tumor immunotherapy.Genes and Immunity advance online publication, 4 October 2012; doi:10.1038/gene.2012.45. |
| | |
Authors:
|
S Min; L Li; M Zhang; Y Zhang; X Liang; Y Xie; Q He; Y Li; J Sun; Q Liu; X Jiang; Y Zhang; Y Che; R Yang |
Related Documents
:
|
6092068 - Nucleoside diphosphate kinase from brain. purification and effect on microtubule assemb... 23498918 - Discovery of n-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-m... 19400808 - Stimulation of the potassium sensor kdpd kinase activity by interaction with the phosph... 23583378 - Metastasis suppressor nm23-h1 inhibits stat3 signaling via a negative feedback mechanism. 10593908 - A point mutation in a plant calmodulin is responsible for its inhibition of nitric-oxid... 15735648 - Alternative p38 activation pathway mediated by t cell receptor-proximal tyrosine kinases. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-04 |
Journal Detail:
|
Title: Genes and immunity Volume: - ISSN: 1476-5470 ISO Abbreviation: Genes Immun. Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100953417 Medline TA: Genes Immun Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Immunology, Nankai University School of Medicine, Tianjin, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bioelectrode-based approach for enhancing nitrate and nitrite removal and electricity generation fro...
Next Document: Antioxidant properties and cytotoxic effects on human cancer cell lines of aqueous fermented and lip...