| TGFβ and BMP signaling in cardiac cushion formation: Lessons from mice and chicken. | |
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MedLine Citation:
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PMID: 22656450 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cardiac cushion formation is crucial for both valvular and septal development. Disruption in this process can lead to valvular and septal malformations, which constitute the largest part of congenital heart defects. One of the signaling pathways that is important for cushion formation is the TGFβ superfamily. The involvement of TGFβ and BMP signaling pathways in cardiac cushion formation has been intensively studied using chicken in vitro explant assays and in genetically modified mice. In this review, we will summarize and discuss the role of TGFβ and BMP signaling components in cardiac cushion formation. |
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Authors:
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Boudewijn P T Kruithof; Sjoerd N Duim; Asja T Moerkamp; Marie-José Goumans |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-30 |
Journal Detail:
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Title: Differentiation; research in biological diversity Volume: - ISSN: 1432-0436 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-6-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401650 Medline TA: Differentiation Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 International Society of Differentiation. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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